Results 51 to 60 of about 2,209,767 (280)

Development of a patient-centered asthma action plan for single maintenance and reliever therapy (MART)

Journal of Allergy and Clinical Immunology: Global
Background: Recent guidelines recommend maintenance and reliever therapy (MART) as the preferred inhaler regimen for patients with moderate to severe asthma.
Shria Bucha, BS, Hannah Kim, BA, Khadijah Kareem, MPH, Christine Watridge, BA, Penina Laker, MFA, Amber Clover, MPH, Ross C. Brownson, PhD, Krutika Chuahan, MD, MPH, Kaharu Sumino, MD, MPH, Mario Castro, MD, MPH, Mark D. Huffman, MD, MPH, James G. Krings, MD, MSc   +11 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Self-reflexive videogames: observations and corollaries on virtual worlds as philosophical artifacts

G|A|M|E The Italian Journal of Game Studies, 2016
Self-reflexive videogames are videogames designed to materialize critical and/or satirical perspectives on the ways in which videogames themselves are designed, played, sold, manipulated, experienced, and understood as social objects.
Stefano Gualeni
doaj  

Impact of smoking reduction on lung cancer risk in patients with COPD who smoked fewer than 30 pack-years: a nationwide population-based cohort study

Respiratory Research
Background The effects of smoking reduction on the incidence of lung cancer in patients with chronic obstructive pulmonary disease (COPD) are not well known. This study aimed to investigate the effects of changes in smoking habits after COPD diagnosis on
Sun Hye Shin, Taeyun Kim, Hyunsoo Kim, Juhee Cho, Danbee Kang, Hye Yun Park   +5 more
doaj   +1 more source

Why Critical design is useless

, 2017
Critical design is proliferating. According to Raby, this kind of design creates artefacts in order to “challenge narrow assumptions, preconceptions, and givens about the role products play in everyday life” (Raby, 2008, 94). Conceived basically as "useless", the value of critical design “ultimately lies in its ability to valuate: articulate, refuse ...
openaire   +2 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Critical design parameters for garages

Građevinar, 2013
The acceptability, usability, and economic success of garages depend on the quality of their design. Only minimum or even lower requirements are often applied.
Rudolf Eger
doaj   +1 more source

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source