Results 81 to 90 of about 13,116,615 (226)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Trace: Design Project and Critical Reflection [PDF]

, 2018
With a view to publication we reformatted our project Trace as a picture essay. Here we argue that our research explores questions of architectural scholarship through the medium of the architectural design project.
Dean, C., Watson, V.A., Santo, D.
core   +1 more source

Development of a patient-centered asthma action plan for single maintenance and reliever therapy (MART)

Journal of Allergy and Clinical Immunology: Global
Background: Recent guidelines recommend maintenance and reliever therapy (MART) as the preferred inhaler regimen for patients with moderate to severe asthma.
Shria Bucha, BS, Hannah Kim, BA, Khadijah Kareem, MPH, Christine Watridge, BA, Penina Laker, MFA, Amber Clover, MPH, Ross C. Brownson, PhD, Krutika Chuahan, MD, MPH, Kaharu Sumino, MD, MPH, Mario Castro, MD, MPH, Mark D. Huffman, MD, MPH, James G. Krings, MD, MSc   +11 more
doaj   +1 more source

Critical design parameters for garages

Građevinar, 2013
The acceptability, usability, and economic success of garages depend on the quality of their design. Only minimum or even lower requirements are often applied.
Rudolf Eger
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Determinant moments for the design management occurrence in fashion industry [PDF]

, 2018
Design management has occupied a privileged place in debates related to the field of design and innovation in fashion industry. The apparel industry, in particular, presents a dynamic character, requiring constant updates on raw materials, changes in ...
Libânio, Cláudia de Souza, Amaral, Fernando Goncalves, Migowski, Sérgio Almeida, Fernando Gonçalves Amaral, Sérgio Almeida Migowski, Cláudia de Souza Libânio   +5 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source