Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
A Procedure for Managing Conflict of Interest When Forming Thesis Juries
Conflicts of interest in thesis juries, when not identified and appropriately managed, can lead to an uncritical and unfair evaluations that can then undermine trust in the process and threaten academic credibility and institutional reputation.
Williams-Jones, Bryn
doaj
On Pulsar Distance Measurements and their Uncertainties [PDF]
Accurate distances to pulsars can be used for a variety of studies of the Galaxy and its electron content. However, most distance measures to pulsars have been derived from the absorption (or lack thereof) of pulsar emission by Galactic HI gas, which ...
A. A. Chael +38 more
core +3 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
On the application of the Theory of Critical Distances for prediction of fracture in fibre composites [PDF]
This paper is concerned with the fracture of composite materials containing stress concentration features such as notches and holes. In particular, it addresses the question of the use of the Theory of Critical Distances (TCD) – a method which is widely ...
David Taylor
doaj
Correlation Functions of a Conformal Field Theory in Three Dimensions [PDF]
We derive explicit forms of the two--point correlation functions of the $O(N)$ non-linear sigma model at the critical point, in the large $N$ limit, on various three dimensional manifolds of constant curvature.
Guruswamy, S., Vitale, P.
core +3 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
The Euclidean distance degree of an algebraic variety [PDF]
The nearest point map of a real algebraic variety with respect to Euclidean distance is an algebraic function. For instance, for varieties of low rank matrices, the Eckart-Young Theorem states that this map is given by the singular value decomposition ...
Draisma, Jan +4 more
core +2 more sources
Tunable Casimir repulsion with three dimensional topological insulators
In this Letter, we show that switching between repulsive and attractive Casimir forces by means of external tunable parameters could be realized with two topological insulator plates.
Adolfo G. Grushin +2 more
core +1 more source

