Results 71 to 80 of about 3,443,652 (334)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Surface critical behavior of fluids: Lennard-Jones fluid near weakly attractive substrate

, 2004
The phase behavior of fluids near weakly attractive substrates is studied by computer simulations of the coexistence curve of a Lennard-Jones (LJ) fluid confined in a slitlike pore.
A. Geiger, A. Oleinikova, Agrawal, Bagnuls, Barosso, Binder, Binder, Binder, Binder, Binder, Bray, Brovchenko, Brovchenko, Burkhardt, Caillol, Camp, Chen, Corti, Diehl, Diehl, Durian, Ebner, Ebner, Errington, Fenzl, Fisher, Fisher, Guida, Hansen, I. Brovchenko, Johnson, Kim, Kim, Litniewski, Lotfi, Maciolek, Nakanishi, Nightingale, Orkoulas, Panagiotopoulos, Panagiotopoulos, Pandit, Potoff, Potoff, Sengers, Shell, Sigl, Singh, Smit, Talapov, Trokhymchuk, Valleau, Valleau, Wegner, Wilding, Yan, Yan   +56 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Critical behavior of the long-range Ising chain from the largest-cluster probability distribution

, 2000
Monte Carlo simulations of the 1D Ising model with ferromagnetic interactions decaying with distance $r$ as $1/r^{1+\sigma}$ are performed by applying the Swendsen-Wang cluster algorithm with cumulative probabilities.
A. Coniglio, A. Margolina, Ante Aničić, C. M. Fortuin, D. J. Thouless, D. Stauffer, E. Luijten, E. Luijten, E. Luijten, E. Luijten, F. J. Dyson, F. Y. Wu, J. F. Nagle, J. Fröhlich, J. L. Monroe, J. L. Monroe, J. M. Kosterlitz, J. Machta, J. Machta, K. Binder, Katarina Uzelac, M. D’Onorio Meo, M. E. Fisher, M. E. Fisher, M. Kretch, M. Z. Bazant, P. W. Anderson, P. W. Kasteleyn, R. H. Swendsen, S. A. Cannas, U. Wolff, Z. Glumac, Z. Glumac, Z. Glumac, Zvonko Glumac   +34 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Total $k$-distance domination critical graphs [PDF]

Transactions on Combinatorics, 2016
A set $S$ of vertices in a graph $G=(V,E)$ is called a total$k$-distance dominating set if every vertex in $V$ is withindistance $k$ of a vertex in $S$.
Doost Ali Mojdeh, A. Sayed-Khalkhali, Hossein Abdollahzadeh Ahangar, Yancai Zhao   +3 more
doaj  

Metric Distance Ranking Technique for Fuzzy Critical Path Analysis

Journal of Applied Sciences and Environmental Management, 2015
In this paper, fuzzy critical path analysis of a project network is carried out. Metric distance ranking technique is used to order fuzzy numbers during the forward and backward pass computations to obtain the earliest start, earliest finish, latest ...
MH Oladeinde, CA Oladeinde
doaj   +1 more source

185 Tuning the cell-cell distance via the non-signaling extracellular spacer domain of chimeric antigen receptors is critical for optimal activity [PDF]

, 2022
Jason K. Yokoyama, Lisa Song, Q. David Walker, Bijan Boldajipour, Howell Moffett, Brian D. Weitzner, Scott E. Boyken, Marc J. Lajoie   +7 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source