Results 81 to 90 of about 911,723 (304)

The theory of critical distances applied to problems in fracture and fatigue of bone [PDF]

open access: yesFracture and Structural Integrity, 2009
The theory of critical distances (TCD) has been applied to predict notch-based fracture and fatigue in a wide range of materials and components. The present paper describes a series of projects in which we applied this approach to human bone.
Emma Brazel, Saeid Kasiri, David Taylor
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Effectiveness of Online Patient Safety Education on the Competency of Nurses in Intensive Care Units: A Quasi-experimental Study

open access: yesنشریه پرستاری ایران, 2022
Background & Aims: Maintaining patient safety (PS) is one of professional and ethical duties of health care providers. Nurses, as the largest professional group in the health system, have a potential and significant power in influencing the health care ...
Tahereh Najafi Ghezeljeh   +3 more
doaj  

Path analysis from COVID-19 perceptions to psychological health: The roles of critical distance and mastery. [PDF]

open access: yesClin Psychol Psychother, 2022
Faustino B   +5 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Critical Thinking and Literacy Skills in Student Scientific Writing: Evidence from Universitas Terbuka

open access: yesInspiring
Teaching scientific writing has been compulsory in many Indonesian universities. It is usually the main indicator for completing an undergraduate program.
Siti Hadianti
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

The Nature of Practitioner Research: Critical distance, power and ethics [PDF]

open access: yes, 2013
Researching within one’s place of practice allows the researcher to have the unique position of knowing the participants and the research context. The relationship the participants have with the researcher will impact upon the disclosure of information ...
Appleby, M.   +2 more
core  

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Resistance distance, information centrality, node vulnerability and vibrations in complex networks

open access: yes, 2010
We discuss three seemingly unrelated quantities that have been introduced in different fields of science for complex networks. The three quantities are the resistance distance, the information centrality and the node displacement.
Estrada, Ernesto   +3 more
core   +1 more source

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