Results 51 to 60 of about 6,798,995 (301)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

The sociology of diagnosis: Critical distance

Sociology of Health & Illness
No description ...
Bell, AV, Jutel, Annemarie, Weinberg, D, Young, Jessica   +3 more
openaire   +2 more sources

La coopération entre concepteurs et tuteurs et l’évolution du rôle du tuteur dans un établissement unimodal d’enseignement à distance

, 2017
In distance education, a separation of roles between course design teams and student support teams are still characteristic of many specialized institutions.
Poellhuber, Bruno, Florent Michelot, Chomienne, Martine, Marie-Noëlle, Fortin, Florent, Michelot, Martine Chomienne, Fortin, Marie-Noëlle, Bruno Poellhuber, Michelot, Florent, Marie-Noëlle Fortin   +9 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Exploring A Transactional Distance-Based Management Model To Improve Perception Of Efficacy Within Designated Corporate Collaboration Communities [PDF]

, 2017
Oil and Gas (O&G) companies are adopting blended learning models to move away from traditional face-to-face training programs that are viewed as costly and less efficient.
Workman, Timothy Peter
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Study on the Influence of Structural Dimensions on Plate Deflection Under Confined Blast

Applied Sciences
The damage assessment of structures subjected to confined internal blast remains a focal point in the field of explosion. However, current research results are mostly limited to the situation where the cabin structure dimensions remain constant, and the ...
Zirui Fan, Jianping Yin, Xudong Li, Lanyang Liu   +3 more
doaj   +1 more source

The preliminary successes and drawbacks of a turn to distance design studio learning.

, 2020
It seems the technological campuses of tomorrow have manifested today as an essential and spontaneous response to the COVID-19 world outbreak. This article briefly discusses the current pivot from an on-campus physical design studio curriculum towards a ...
Marshalsey, Lorraine
core