Results 41 to 50 of about 753,226 (247)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Assessment of the Spatial Variation of the Economic Benefits of Urban Green Spaces in a Highly Urbanized Area

Land
Urban green spaces play a vital role in improving the quality of life and well-being of urban residents. However, their economic benefits in different spatial contexts within highly urbanized areas remain a critical yet understudied topic.
Cheol-Joo Cho, Kwangil Cheon, Wanmo Kang
doaj   +1 more source

Decoupling urban and non-urban landslides for susceptibility mapping in transitional landscapes: a case study from Southwestern Constantine, Algeria [PDF]

Natural Hazards and Earth System Sciences
This study develops a framework for decoupling and investigating urban and non-urban landslide mechanisms, focusing on Constantine, Algeria, a city with complex topography and high landslide susceptibility.
Z. Matougui, Y. M. Daksi, M. Dib, C. Benabbas   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Comparative approaches for assessing access to alcohol outlets: exploring the utility of a gravity potential approach. [PDF]

, 2016
BackgroundA growing body of research recommends controlling alcohol availability to reduce harm. Various common approaches, however, provide dramatically different pictures of the physical availability of alcohol.
Grubesic, Tony H, Murray, Alan T, Pridemore, William Alex, Wei, Ran   +3 more
core   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Discrete Midpoint Convexity

, 2019
For a function defined on a convex set in a Euclidean space, midpoint convexity is the property requiring that the value of the function at the midpoint of any line segment is not greater than the average of its values at the endpoints of the line ...
Moriguchi, Satoko, Murota, Kazuo, Tamura, Akihisa, Tardella, Fabio   +3 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Proximity and Distance in Northern Landscape Photography -\ud Contemporary Criticism, Curation, and Practice

, 2020
Matrix of Movement: Post Industrial Wetlands of the North West\ud \ud Tracy Hill considers in her chapter ‘Matrix of Movement’ how wetlands have long been represented as places of darkness, disease and death within Western culture. Despite increasing recognition for the need to readjust our perceptions and to acknowledge their environmental importance ...
White, Darcy, Goldie, Chris, Hill, Tracy, peck, julia, Cronin, Elizabeth, Keiser, Jessica, Harvey, Aileen, Italahti, Mikko, Wriedt, Anne, Quelvennec, Lena, Daly, Tim   +10 more
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