Results 41 to 50 of about 1,891,729 (293)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The effect of notch size on critical distance and fatigue life predictions

Materials & Design, 2020
Notch and size effects generally show great influence on the fatigue behavior of engineering structures, which plays a vital role during their structural integrity and reliability evaluations.
Shun-Peng Zhu, Jin-Chao He, Ding Liao, Qingyuan Wang, Yongjie Liu   +4 more
doaj   +1 more source

Ising spin glass transition in magnetic field out of mean-field

, 2009
The spin-glass transition in external magnetic field is studied both in and out of the limit of validity of mean-field theory on a diluted one dimensional chain of Ising spins where exchange bonds occur with a probability decaying as the inverse power of
Leuzzi, L, Parisi, G., Ricci-Tersenghi, F., Ruiz-Lorenzo, J. J.   +3 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

THEORY OF CRITICAL DISTANCES AND THE THICKNESS OF THE SURFACE LAYER

, 2023
The theory of critical distances is based on the strength of materials L, which is given by its strength properties KIc and σ0. We have shown that the thickness of the surface layer R(I) is equal to the nanocrack length Lnm. We have shown that there is a relationship between L and Lnm: L = 104 Lnm = 104 R(I) ≈ 10-5 М/ρ.
Berdibekov, A.T., Yurov, V.M., Dolya, A.V., Gruzin, V.V.   +3 more
openaire   +1 more source

Quantum structural phase transition in chains of interacting atoms

, 2010
A quasi one--dimensional system of trapped, repulsively interacting atoms (e.g., an ion chain) exhibits a structural phase transition from a linear chain to a zigzag structure, tuned by reducing the transverse trap potential or increasing the particle ...
Fishman, Shmuel, Morigi, Giovanna, Shimshoni, Efrat   +2 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Notched multiaxial fatigue of Al7050-T7451: on the need for an equivalent process zone size [PDF]

Fracture and Structural Integrity, 2017
The aim of this work is to investigate stress gradient effects on the fatigue life estimation of notched Al 7050-T7451 specimens under combined torsion and push-pull loading conditions.
J.L.A Ferreira, C.R.M da Silva , J.A. Araújo   +2 more
doaj   +3 more sources

Critical dynamical heterogeneities close to continuous second-order glass transitions

, 2014
We analyse, using Inhomogenous Mode-Coupling Theory, the critical scaling behaviour of the dynamical susceptibility at a distance epsilon from continuous second-order glass transitions. We find that the dynamical correlation length xi behaves generically
Biroli, Giulio, Bouchaud, Jean-Philippe, Miyazaki, Kunimasa, Nandi, Saroj Kumar, Reichman, David R.   +4 more
core   +3 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source