Results 61 to 70 of about 185,145 (291)
Adaptive Metrics for Adaptive Samples
Algorithms, 2020 We generalize the local-feature size definition of adaptive sampling used in surface reconstruction to relate it to an alternative metric on Euclidean space.
Nicholas J. Cavanna, Donald R. Sheehy
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Resistance distance, information centrality, node vulnerability and vibrations in complex networks
, 2010 We discuss three seemingly unrelated quantities that have been introduced in different fields of science for complex networks. The three quantities are the resistance distance, the information centrality and the node displacement.
Estrada, Ernesto +3 more
core +1 more source
Evaluation of notch effects in low cycle fatigue of alloy 718 using critical distances
MATEC Web of Conferences, 2018 Gas turbine disks contain many notch-like features acting as stress raisers. The fatigue life based on the notch root stress may be overly conservative as the steep stress gradient in front of the notch may give rise to so-called notch support.
Eriksson Robert +3 more
doaj +1 more source
Some Applications of Critical Point Theory of Distance Functions on Riemannian Manifolds [PDF]
Compositio Mathematica, 2002 In this paper, we use the theory of critical points of distance functions to study the rigidity and topology of Riemannian manifolds with sectional curvature bounded below. We prove that an n -dimensional complete connected Riemannian manifold M with ...
openaire +2 more sources
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Take AIM and Keep Your Students Engaged
Journal of Open, Flexible and Distance Learning, 2014 This paper outlines the benefits to distance education teachers of formatting a weekly online newsletter in accordance with motivational learning theory.
Catherine Theresa Mary Nash
doaj +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Book Review: Critical Digital Pedagogy in Higher Education
Open PraxisThis review of Critical Digital Pedagogy in Higher Education by Carlos Eduardo Flores Moreno explores the different sections and chapters presented in the book: “Shared Learning and Trust”, that focuses on alternative teaching methods; “Critical ...
Carlos Eduardo Flores Moreno
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source