Results 71 to 80 of about 6,001,986 (284)

Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and Susceptibility in Aged Muscle

Advanced Science, EarlyView.
Repeated disuse imprints a molecular memory in skeletal muscle, conferring transcriptional resilience in young adults but exaggerated susceptibility in aged muscle, driven by epigenetic regulation of aerobic metabolism, mitochondrial and NAD+ pathways.
Daniel C. Turner, Truls Raastad, Max Ullrich, Stian F. Christiansen, Hazel Sutherland, James Boot, Eva Wozniak, Charles Mein, Emilie Dalbram, Jonas T. Treebak, Daniel J. Owens, David C. Hughes, Sue C. Bodine, Jonathan C. Jarvis, Adam P. Sharples   +14 more
wiley   +1 more source

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

Sub‐Unit‐Cell Logic Governs Transport in TPMS Architectures

Advanced Science, EarlyView.
ABSTRACT Next‐generation energy, thermal, and chemical systems require architectures capable of highly efficient transport across multiple length scales. Triply periodic minimal surfaces (TPMS), first conceptualized in 1865, offer inherently scalable geometries with exceptional transport potential, yet mechanistic links between topology and performance
Haozhang Zhong, Yipei He, Jiaxuan Wang, Chenyi Qian, Gerd E Schröder‐Turk, Raj Das, Junye Shi, Qi Tang, Zheda Ning, Wenjue Yi, Chuanwei Li, Jiangping Chen, Zeyao Chen, Binbin Yu, Jian LU, Jianfeng Gu, Ma Qian   +16 more
wiley   +1 more source

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation

Advanced Science, EarlyView.
Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng, Ge Zhu, Siyu Sun, Wenbo Yao, Yuning Zhang, Yong‐Guang Yang, Tianmeng Sun   +6 more
wiley   +1 more source

Distinct Biotypes of Visual Perception in Major Depressive Disorder

Advanced Science, EarlyView.
In a discover dataset (272 acute MDD patients), this work identifies a novel depression biotype characterized by impaired visual motion perception, using machine learning clustering. An independent dataset confirms the robustness of this biotype through cross‐validation and demonstrates its generalizability.
Zhuoran Cai, Xi‐Wen Hu, Yuyang Li, Zheng Lin, Yongjie Li, Yong‐Chun Cai, Tao Xu, Ke Jia, Jin‐Fang Han, Zhong‐Lin Tan, Dezhong Yao, Xue Mei Song, Sugai Liang, Georg Northoff   +13 more
wiley   +1 more source

Texts and computations, mechanisms and abstractions. Dualism and digital editions

JLIS.it, 2019
Critical thinking on digital editions, and in particular scholarly editions, has been so far mainly focused on redefining the theoretical aspects developed in an analogical dimension, such as textual orientations, following a technological approach.
Federico Meschini
doaj   +6 more sources

Il processo editoriale delle prime edizioni italiane del 'Tristram Shandy'

Prassi Ecdotiche della Modernità Letteraria, 2019
Questo articolo ricostruisce, attraverso l’analisi di documenti di archivio, il processo editoriale delle prime due edizioni italiane del Tristram Shandy di Laurence Sterne: quella pubblicata nei «Classici del Ridere» dall’editore Formiggini (1922) e ...
Mariano D'Ambrosio
doaj   +1 more source

Stability of Perovskite Indoor Photovoltaics: A Focused Review and a Call for Standardized Stability Reporting

Advanced Energy Materials, EarlyView.
While perovskite solar cells have been widely studied, including their stability, perovskite indoor photovoltaics (IPVs) have only recently emerged. Nevertheless, more studies are appearing in the literature. The systematic stability study of IPVs is crucial, particularly given the inconsistencies in reported methodologies and results, which call for ...
Ivy Mawusi Asuo, Arezo Mahdavi Varposhti, Cyril Chu Fubin Kumachang, Gopal Krishnamurthy Grandhi, Vincenzo Pecunia, Thomas Meredith Brown, Paola Vivo, Nutifafa Yao Doumon   +7 more
wiley   +1 more source

Accounting for Substitution: Improving Estimates of GHG Reductions From Cattle‐Based Product Demand Shifts

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Estimates of reductions in greenhouse gas (GHG) emissions from lower demand for cattle‐based products must account for substitution effects. This study collected data through two surveys—one on ground beef and another on dairy milk—to evaluate substitution effects and potential GHG reductions.
Brandon R. McFadden, Sara Gardner Hedgecock, Lawton L. Nalley, Alvaro Durand‐Morat, Aaron Shew, Rodolfo M. Nayga Jr   +5 more
wiley   +1 more source

Does ESG Matter for Unlisted Companies in the Agri‐Food Industry? Evidence From Japan's Unlisted Agri‐Food Companies

Agribusiness, EarlyView.
ABSTRACT While ESG (environmental, social, and governance) is emphasized among listed companies for their stakeholders and ESG disclosures, ESG engagement among unlisted companies has been rarely examined due to data limitations. This is particularly problematic for the agri‐food industry that has significant impacts on the environment and consists ...
Ying Wang, Satoru Shimokawa
wiley   +1 more source