Results 71 to 80 of about 5,091,650 (334)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
First and second critical exponents for an inhomogeneous Schrödinger equation with combined nonlinearities [PDF]
, 2022 Munirah Alotaibi +3 more
openalex +1 more source
Critical exponents of strongly correlated fermion systems from diagrammatic multiscale methods. [PDF]
Physical Review Letters, 2013 Self-consistent dynamical approximations for strongly correlated fermion systems are particularly successful in capturing the dynamical competition of local correlations. In these, the effect of spatially extended degrees of freedom is usually only taken
A. Antipov, E. Gull, S. Kirchner
semanticscholar +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Small perturbations of critical nonlocal equations with variable exponents
Demonstratio Mathematica, 2023 In this article, we are concerned with the following critical nonlocal equation with variable exponents: (−Δ)p(x,y)su=λf(x,u)+∣u∣q(x)−2uinΩ,u=0inRN\Ω,\left\{\begin{array}{ll}{\left(-\Delta )}_{p\left(x,y)}^{s}u=\lambda f\left(x,u)+{| u| }^{q\left(x)-2}u&
Tao Lulu, He Rui, Liang Sihua
doaj +1 more source
Critical exponent of binary words with few distinct palindromes [PDF]
, 2023 Ľubomíra Dvořáková +2 more
openalex +1 more source
On a p-Laplacian system with critical Hardy–Sobolev exponents and critical Sobolev exponents [PDF]
Ukrainian Mathematical Journal, 2012 In this paper, the existence results of positive solutions for the semiliner elliptic system \[ \begin{cases} -\text{div} (|\nabla u_i|^{p-2} \nabla u_i) - \mu \frac{|u_i|^{p-2}u_i}{|x|^p} \\ = \frac{1}{p^*} F_{u_i}(u_1,\ldots,u_k) + \frac{|u_i|^{p^*(t)-2}u_i}{|x|^t} + \lambda \frac{|u_i|^{p-2}u_i}{|x|^s}, \quad x \in \Omega, \\ u_i=0 \quad \text{on} \;
openaire +3 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source