Results 181 to 190 of about 856,163 (286)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Remote real time digital monitoring fills a critical gap in the management of Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Negi AS, Karjagi S, Parisi L, Daley KW, Abay AK, Gala AS, Wilkins KB, Hoffman SL, Ferris MS, Zahed H, Chattree GM, Palushaj B, Bronte-Stewart HM.   +12 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Segregation and the Attainment of Minority Ethnic Pupils in England [PDF]

In this paper we ask whether ethnic segregation in schools and in neighbourhoods has a causal effect on differential school attainment. We ask two related but different questions.
Simon Burgess, Adam Briggs, Anete Piebalga, Deborah Wilson   +3 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Potential Output and the Output Gap in Ireland [PDF]

The performance of the Irish economy in recent years has been outstanding. Between 1994 and 2000, Ireland’s economic growth, as measured by the annual percentage change in real GDP (Gross Domestic Product), has expanded at an annual average rate of ...
Slevin, Geraldine
core  

The Research Fairness Initiative: Filling a critical gap in global research ethics. [PDF]

Gates Open Res, 2018
Lavery JV, IJsselmuiden C.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A Critical Gap in Addressing Mental Health in Heat-Health Action Plans Worldwide. [PDF]

Curr Environ Health Rep
Stewart-Ruano A, Spriggs R, Lawrance EL, Massazza A, Czerniewska A, Reale AS, Shumake-Guillemot J, Keyes KM, Van Horne YO, Parks RM.   +9 more
europepmc   +1 more source

Polar Ocean Observations: A Critical Gap in the Observing System and Its Effect on Environmental Predictions From Hours to a Season. [PDF]

Front Mar Sci, 2019
Smith GC, Allard R, Babin M, Bertino L, Chevallier M, Corlett G, Crout J, Davidson F, Delille B, Gille ST, Hebert D, Hyder P, Intrieri J, Lagunas J, Larnicol G, Kaminski T, Kater B, Kauker F, Marec C, Mazloff M, Metzger EJ, Mordy C, O'Carroll A, Olsen SM, Phelps M, Posey P, Prandi P, Rehm E, Reid P, Rigor I, Sandven S, Shupe M, Swart S, Smedstad OM, Solomon A, Storto A, Thibaut P, Toole J, Wood K, Xie J, Yang Q, WWRP PPP Steering Group.   +41 more
europepmc   +1 more source