Results 221 to 230 of about 13,752,706 (262)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

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Group and person attributions in response to criticism of the in‐group

British Journal of Social Psychology, 2002
This study examined responses to criticism of the in‐group as influenced by critic's group membership and justifiability of the criticism. Participants responded to an article in which the author criticized their school. The critic was presented as a student either at the participant's own school (the in‐group) or at a college higher or lower in status
Anne, O'Dwyer, Norman H, Berkowitz, David, Alfeld-Johnson   +2 more
openaire   +2 more sources

On critical groups

Siberian Mathematical Journal, 1992
An elementary proof of lemma 52.23 of \textit{H. Neumann} [Varieties of groups (1967; Zbl 0251.20001)] is given, which has a central place in obtaining the fact that the identities of a finite group have a finite basis.
openaire   +2 more sources

On homogeneity within critical groups

Journal of Radiological Protection, 2004
Since the 1960s, the methodology recommended by the International Commission on Radiological Protection (ICRP) for assessment of individual doses has developed significantly, yet the specific recommendations related to the characteristics of 'critical groups' for the purposes of protection of the public have been interpreted but are relatively ...
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Critical sets in a family of groups

Australas. J Comb., 1997
The authors construct a partial latin square which is a critical set in the latin square corresponding to the latin square of the group of order \(4h\), \(h \geq 2\), with generating relations \(a^{2h}=1\), \(b^2=a^h\) and \(ba=a^{-1}b\).
Diane M. Donovan, D. G. Hoffman
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Critical degenerate inequalities¶on the Heisenberg group

manuscripta mathematica, 2001
The author obtains necessary conditions for the existence of (signed) weak solutions for the singular inequalities on the Heisenberg group: \({{-| \xi| ^2_{H}}\over {\psi}} \Delta_H (au) \geq | u| ^q,\) on \(I\!\! H^n \setminus\{0\}\) \; \(u_t -{{| \xi| ^2_{H}}\over {\psi}} \Delta_H (au) \geq | u| ^q,\) and \(u_{tt} -{{| \xi| ^2_{H}}\over {\psi ...
openaire   +4 more sources