Results 261 to 270 of about 3,452,336 (316)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE): A Protocol for a Pre-Planned Sub-Study of a Randomized Clinical Trial. [PDF]

Acta Anaesthesiol Scand
M KK, V H N, P Y, N N, M P W, M R, F B, G L, J D, N H, J H, H L, M MK, M S, M T, A C, C B K, C D B S, D A, S S, J T, T O, H S, S B, J D, A L, J J, J U, A L, J K, J G, E L, L R, P S, P S, T G, A M, C L, J N, P D, K A, P J M, J W, M G, M O, P H, A P, R H, D P, P J, A N, M H, M P H, M I, C S, M N, M J, C R, J B, D R, Y A, A AF, C YW, A A, A S, C A, M R, R P, A D, M R, B V, F T, P T P, H F, T C, J C J, M B S.   +76 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Lower airway dysbiosis in nontuberculous mycobacteria-positive bronchiectasis is associated with neutrophil extracellular trap-predominant severe phenotypes. [PDF]

Am J Respir Crit Care Med
Singh S, Darawshy F, Erlandson K, Narayana JK, Li Q, Li Y, Atandi I, Krolikowski K, Patel S, Collazo D, Mac Aogáin M, Gilmour A, Long M, Chang M, Hoque A, Schluger R, Kumar S, Chung CJ, Wong K, Porter G, Feng Y, Czachor A, McCormick C, Clementi E, Kyeremateng Y, Lukovnikova A, Harris D, Gomez S, Kain T, Kocak I, Singh R, Rodriguez C, Kwok B, Barnett C, Kugler M, Weiden MD, Nelson N, Natalini JG, Luglio D, Desvignes L, Gautam S, McGuire E, Gordon T, Sulaiman I, Tsay JJ, Basavaraj A, Wu BG, Kamelhar D, Addrizzo-Harris D, Chalmers JD, Chotirmall SH, Segal LN.   +51 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Ventilator waveform interpretation skills of attending intensivists relative to critical care fellows (VISA) study. [PDF]

ATS Sch
Amirahmadi R, Alnababteh M, Keller M, Sun J, Bagavathy K, Safadi S, Staitieh BS, Maximous SI, Kriner E, Woods CJ, Oweis E, Schreiber MP, Seam N, Lee BW, Critical Care Education Research Consortium .   +14 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Oligomer logic of memory molecules. [PDF]

Mol Brain
Rudy JW.
europepmc   +1 more source

Clinical Utility and Safety of Bone Cement Augmentation in Intramedullary Nailing for Proximal Femur Fractures: A Multicenter Prospective Observational Study. [PDF]

Geriatr Orthop Surg Rehabil
Matsumoto M, Choe H, Kobayashi N, Yamamoto K, Matsuo K, Makita H, Enomoto D, Hieda Y, Inaba Y.   +8 more
europepmc   +1 more source