Results 241 to 250 of about 6,342,270 (352)

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

The impact of VaKE-driven online discussions on critical thinking styles among Chinese undergraduates. [PDF]

Front Psychol
Xu X, Su Y, Zhang H, Lei VN, Ye X.
europepmc   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

A 218 Neutron Group Master Cross Section Library for Criticality Safety Studies

, 1975
William E. Ford, R.M. Westfall, C.C. Webster   +2 more
openalex   +1 more source

Transcriptomic profiling of severe and critical COVID-19 patients reveals alterations in expression, splicing and polyadenylation. [PDF]

Sci Rep
Labrecque M, Brunet-Ratnasingham E, Hamilton LK, Auld D, Montpetit A, Richards B, Durand M, Rousseau S, Finzi A, Kaufmann DE, Tetreault M.   +10 more
europepmc   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

ATP Binding Is Critical for the Conformational Change from an Open to Closed State in Archaeal Group II Chaperonin [PDF]

, 2003
Ryo Iizuka, Takao Yoshida, Yasuhito Shomura, Kunio Miki, Tadashi Maruyama, Masafumi Odaka, Masafumi Yohda   +6 more
openalex   +1 more source

Unraveling the COVID-19 Severity Hubs and Interplays in Inflammatory-Related RNA-Protein Networks. [PDF]

Int J Mol Sci
Park H, Wang QS, Hasegawa T, Namkoong H, Tanaka H, Koike R, Kitagawa Y, Kimura A, Imoto S, Kanai T, Fukunaga K, Ogawa S, Okada Y, Miyano S.   +13 more
europepmc   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Critical thermodynamics of the two-dimensional systems in five-loop renormalization-group approximation

, 2000
E. V. Orlov, A. I. Sokolov
openalex   +2 more sources