Results 221 to 230 of about 12,929,549 (289)

Climate-Resilient Disaster Preparedness Education to Strengthen Undergraduate Nurses' Critical Care-Relevant Skills: A Quasi-Experimental Study From Saudi Arabia. [PDF]

Nurs Crit Care
Alanazi MA, Shaban M.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Cirrhosis Impairs Reconstitution of the Circulating T-Lymphocyte Compartment After Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection. [PDF]

United European Gastroenterol J
Paule L, Castillo E, Muñoz L, Martínez J, Fernández C, Miranda A, Lario M, Monserrat J, Ortega MÁ, Calleja JL, Álvarez-Mon M, Albillos A.   +11 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Developing a Shared Understanding of Humanism in Health Care Through Critical Review and Empirical Exploration: Protocol for a Modified e-Delphi Study. [PDF]

JMIR Res Protoc
Guay D, Turcotte A, April MJ, Foley V, Beauchamp J, Marquis N, Héon-Lepage M.   +6 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The hidden severity of new psychoactive substances: clinical evidence from emergency and intensive care admissions in Taiwan. [PDF]

Ann Intensive Care
Liao PH, Lin CC, Chang CM, Liu SW, Weng TI, Chen HY, Fang CC, Yu JH, Su YJ, Chen YC.   +9 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Thermal Phase Behavior of PNIPAM-Based Hydrogels: Different Scenarios and Implications in Injectable Hydrogel Design. [PDF]

Gels
Kotova SL, Kukanova VS, Kostjuk SV, Efremov YM, Rochev YA, Frolova AA, Timashev PS.   +6 more
europepmc   +1 more source