Results 121 to 130 of about 5,391,473 (290)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Existence of multiple positive solutions for fractional Laplace problems with critical growth
Electronic Journal of Differential Equations, 2021 Yajing Zhang, Qiaoqin Li, Lu Pang
doaj
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Sharp Trudinger-Moser inequalities with homogeneous weights
Electronic Journal of Differential Equations, 2019 We investigate sharp Trudinger-Moser type inequalities with the homogeneous weight satisfying a natural curvature-dimension bound condition. Also we study the optimal versions of these inequalities with best constants on both finite and infinite ...
Nguyen Tuan Duy +2 more
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Identification of critical growth factors for peripheral nerve regeneration. [PDF]
RSC Adv, 2019 Zhang R, Zhang Y, Yi S.
europepmc +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
p-Kirchhoff type problem with a general critical nonlinearity
Electronic Journal of Differential Equations, 2018 In this article, we consider the p-Kirchhoff type problem $$ \Big(1+\lambda\int_{\mathbb{R}^N}|\nabla u|^p +\lambda b\int_{\mathbb{R}^N}|u|^p\Big)(-\Delta_p u+b|u|^{p-2}u) =f(u), x\in\mathbb{R}^N, $$ where $\lambda>0$, the nonlinearity f can reach ...
Huixing Zhang, Baiquan Lin
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On Kirchhoff-Schrödinger-Poisson-type systems with singular and critical nonlinearity
Advances in Nonlinear AnalysisThis work focuses on the Kirchhoff-Schrödinger-Poisson-type system with singular term and critical Sobolev nonlinearity as follows: −a+b∫Ω∣∇u∣pdxΔpu+ϕ∣u∣q−2u=λu−γ+∣u∣p∗−2uinΩ,−Δϕ=∣u∣qinΩ,u=ϕ=0on∂Ω,\left\{\begin{array}{ll}-\left(a+b\mathop{\displaystyle ...
Yang Baoling, Zhang Deli, Liang Sihua
doaj +1 more source