Results 111 to 120 of about 5,391,473 (290)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Elliptic equations with one-sided critical growth

Electronic Journal of Differential Equations, 2002
We consider elliptic equations in bounded domains $Omegasubset mathbb{R}^N $ with nonlinearities which have critical growth at $+infty$ and linear growth $lambda$ at $-infty$, with $lambda > lambda_1$, the first eigenvalue of the Laplacian. We prove that
Marta Calanchi, Bernhard Ruf
doaj  

Multiple solutions for a class of fourth-order elliptic equations with critical growth

Open Mathematics
In this article, we study the semilinear biharmonic problem with a critical growth: Δ2u=μQ(x)∣u∣p−2u+V(x)∣u∣2**−2uinΩ,u=Δu=0on∂Ω,\left\{\begin{array}{ll}{\Delta }^{2}u=\mu Q\left(x){| u| }^{p-2}u+V\left(x){| u| }^{{2}^{* * }-2}u\hspace{1.0em}& \hspace{0 ...
Tian Guaiqi, Lei Jun, An Yucheng
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Existence of solutions for critical Henon equations in hyperbolic spaces

Electronic Journal of Differential Equations, 2013
In this article, we use variational methods to prove that for a suitable value of $lambda$, the problem $$displaylines{ -Delta_{mathbb{B}^N}u=(d(x))^{alpha}|u|^{2^{*}-2}u+lambda u, quad ugeq 0,quad uin H_0^1(Omega') }$$ possesses at least one non ...
Haiyang He, Jing Qiu
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Existence of Solutions for a Perturbed N-Laplacian Boundary Value Problem with Critical Growth

Axioms
In this paper, we investigate a perturbed elliptic boundary value problem that exhibits critical growth characterized by a Trudinger–Moser-type inequality. Our primary focus is to establish the existence of two nontrivial solutions.
Sheng Shi, Yang Yang
doaj   +1 more source

Critical percentiles for equalizing growth [PDF]

, 2015
This paper provides precise conditions under which incremental growth reduces inequality. Critical points are derived, above which incremental income increases inequality, and below which it decreases inequality. According to the Gini coefficient, the lower bound for this critical point is the median individual. Surprisingly, critical points associated
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source