Results 111 to 120 of about 1,868,596 (269)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Sharp Trudinger-Moser inequalities with homogeneous weights
Electronic Journal of Differential Equations, 2019 We investigate sharp Trudinger-Moser type inequalities with the homogeneous weight satisfying a natural curvature-dimension bound condition. Also we study the optimal versions of these inequalities with best constants on both finite and infinite ...
Nguyen Tuan Duy +2 more
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
p-Kirchhoff type problem with a general critical nonlinearity
Electronic Journal of Differential Equations, 2018 In this article, we consider the p-Kirchhoff type problem $$ \Big(1+\lambda\int_{\mathbb{R}^N}|\nabla u|^p +\lambda b\int_{\mathbb{R}^N}|u|^p\Big)(-\Delta_p u+b|u|^{p-2}u) =f(u), x\in\mathbb{R}^N, $$ where $\lambda>0$, the nonlinearity f can reach ...
Huixing Zhang, Baiquan Lin
doaj
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Solutions to singular quasilinear elliptic equations on bounded domains
Electronic Journal of Differential Equations, 2018 In this article we study quasilinear elliptic equations with a singular operator and at critical Sobolev growth. We prove the existence of positive solutions.
Zhouxin Li, Youjun Wang
doaj
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source