Results 91 to 100 of about 2,015,439 (266)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
How Wyoming’s Exodus of Young Adults Holds Back Economic Diversification
Wyoming’s longstanding strengths in resource extraction provide much of its livelihood, including its private earnings and public finances. However, its lack of activity in other sectors exposes Wyoming to economic shocks. This paper examines the state’s
O'Brien, Timothy +9 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
A Growth Rate for a Sustainable Economy [PDF]
A sustainable growth rate – i.e. a growth rate which allows economy to expand without compromising the equilibrium of the natural system – is one of the most important and stimulating topics in growth literature.
Alessio Emanuele BIONDO
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
EPITAXIAL-GROWTH OF HIGHLY STRAINED INXGA1-XAS ON GAAS(001) - THE ROLE OF SURFACE-DIFFUSION LENGTH
The growth of highly strained InxGa1-xAs (x > 0.25) epitaxial layers on GaAs(001) undergoes a 2D-3D growth mode transition beyond a certain ''critical thickness''.
Massjes, J., Grandjean, N.
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
What drives productivity growth?
Economists have long debated the best way to explain the sources of productivity growth. Neoclassical theory and "new growth" theory both regard investment—broadly defined to include purchases of tangible assets, human capital expenditures, and research ...
Kevin J. Stiroh
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Nutrition and Growth : Yearbook 2016 /
, 2016 It is a well-known fact that children's growth depends on the quality of their nutrition. However, the mechanisms of fetal and child growth and their interactions with nutrition have not yet been fully elucidated and still pose a challenge to those ...
Koletzko, B.
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