Results 91 to 100 of about 11,486,155 (229)
Elliptic equations with one-sided critical growth
Electronic Journal of Differential Equations, 2002 We consider elliptic equations in bounded domains $Omegasubset mathbb{R}^N $ with nonlinearities which have critical growth at $+infty$ and linear growth $lambda$ at $-infty$, with $lambda > lambda_1$, the first eigenvalue of the Laplacian. We prove that
Marta Calanchi, Bernhard Ruf
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Multiple solutions for a class of fourth-order elliptic equations with critical growth
Open MathematicsIn this article, we study the semilinear biharmonic problem with a critical growth: Δ2u=μQ(x)∣u∣p−2u+V(x)∣u∣2**−2uinΩ,u=Δu=0on∂Ω,\left\{\begin{array}{ll}{\Delta }^{2}u=\mu Q\left(x){| u| }^{p-2}u+V\left(x){| u| }^{{2}^{* * }-2}u\hspace{1.0em}& \hspace{0 ...
Tian Guaiqi, Lei Jun, An Yucheng
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Existence of solutions for critical Henon equations in hyperbolic spaces
Electronic Journal of Differential Equations, 2013 In this article, we use variational methods to prove that for a suitable value of $lambda$, the problem $$displaylines{ -Delta_{mathbb{B}^N}u=(d(x))^{alpha}|u|^{2^{*}-2}u+lambda u, quad ugeq 0,quad uin H_0^1(Omega') }$$ possesses at least one non ...
Haiyang He, Jing Qiu
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Growth Lab Working Paper Series No. 231In this paper, I argue that a focus on exports, both at the intensive margin (where existing products increase their volume), but especially at the extensive margin (where new products start being exported), can ...
Hausmann, Ricardo
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Existence of multiple positive solutions for fractional Laplace problems with critical growth
Electronic Journal of Differential Equations, 2021 Yajing Zhang, Qiaoqin Li, Lu Pang
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source