Results 81 to 90 of about 5,391,473 (290)

Multiplicity of solutions for quasilinear equations involving critical Orlicz-Sobolev nonlinear terms

Electronic Journal of Differential Equations, 2013
In this work, we study the existence and multiplicity of solutions for a class of problems involving the $\phi$-Laplacian operator in a bounded domain, where the nonlinearity has a critical growth.
Jefferson A. Santos
doaj  

Existence of multiple solutions for a class of nonhomogeneous problems with critical growth

Electronic Journal of Qualitative Theory of Differential Equations, 2017
In this paper, we study the existence and multiplicity of solutions for $(p_1(x),p_2(x))$-equation with critical growth. The technical approach is mainly based on the variational method combined with the genus theory.
Mohammed Massar
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Multiple solutions for a class of Kirchhoff-type equation with critical growth

Electronic Journal of Qualitative Theory of Differential Equations
In this paper, we study the multiplicity of solutions to a class of Kirchhoff-type equation with critical growth $$ -\left(a+b\int_{\mathbb{R}^3}|\nabla u|^2dx\right)\Delta u+V(x)u=\lambda h(x)f(u)+g(x)u^5 \quad \mbox{in }\mathbb{R}^3, $$ where $a$, $b ...
Yiwei Ye, Shan Liu
doaj   +1 more source

The SOX11 transcription factor is a critical regulator of basal-like breast cancer growth, invasion, and basal-like gene expression. [PDF]

, 2016
Basal-like breast cancers (BLBCs) are aggressive breast cancers associated with poor survival. Defining the key drivers of BLBC growth will allow identification of molecules for targeted therapy.
Brown, Powel H, Hilsenbeck, Susan G, Mazumdar, Abhijit, Savage, Michelle, Shepherd, Jonathan H, Tsimelzon, Anna, Uray, Ivan P   +6 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Ground state solutions for asymptotically periodic Schrodinger equations with critical growth

Electronic Journal of Differential Equations, 2013
Using the Nehari manifold and the concentration compactness principle, we study the existence of ground state solutions for asymptotically periodic Schrodinger equations with critical growth.
Hui Zhang, Junxiang Xu, Fubao Zhang
doaj  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source