Results 171 to 180 of about 15,857,552 (384)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Existence of infinitely many solutions for elliptic boundary-value problems with nonsymmetrical critical nonlinearity

Electronic Journal of Differential Equations, 2004
In this paper, we study a semilinear elliptic boundary-value problem involving nonsymmetrical term with critical growth on a bounded smooth domain in $mathbb{R}^n$.
Geng Di
doaj  

Multiplicity and concentration behavior of solutions for the generalized quasilinear Schrödinger equation with critical growth

Demonstratio Mathematica
In this study, we are interested in multiplicity results for positive solutions of the generalized quasilinear Schrödinger equations with critical growth −div(g2(u)∇u)+g(u)g′(u)∣∇u∣2+V(εx)u=∣u∣αp−2u+Q(εx)∣u∣α2*−2u,x∈RN,-\mathrm{div}({g}^{2}\left(u)\nabla
Chen Yongpeng, Yang Zhipeng
doaj   +1 more source

Identification of Critical Genes for Growth in Olive Brine by Transposon Mutagenesis of Lactobacillus pentosus C11 [PDF]

, 2013
Giorgia Perpetuini, Hélène Scornec, Rosanna Tofalo, Pascale Serror, Maria Schirone, Giovanna Suzzi, Aldo Corsetti, Jean‐François Cavin, Hélène Licandro   +8 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Multiplicity and concentration of positive solutions for fractional nonlinear Schrodinger equations with critical growth

Electronic Journal of Differential Equations, 2019
In this article we consider the multiplicity and concentration behavior of positive solutions for the fractional nonlinear Schrodinger equation $$\displaylines{ \varepsilon^{2s}(-\Delta)^{s}u + V(x)u= u^{2^*_s-1} + f(u) , \quad x\in\mathbb{R}^N ...
Xudong Shang, Jihui Zhang
doaj  

Fluence plays a critical role on the subsequent distribution of chemotherapy and tumor growth delay in murine mesothelioma xenografts pre‐treated by photodynamic therapy

, 2015
Yabo Wang, Xingyu Wang, Marie‐Aude Le Bitoux, Georges Wagnières, Hubert Vandenbergh, Michel González, Hans‐Beat Ris, Jean Yannis Perentes, Thorsten Krueger   +8 more
openalex   +2 more sources

Effect of temperature on growth, survival, thermal behavior, and critical thermal maximum in the juveniles of Macrobrachium occidentale (Holthuis, 1950) (Decapoda: Caridea: Palaemonidae) from Mexico [PDF]

, 2018
Pedro Hernández-Sandoval, Fernando Díaz-Herrera, Jesús Manuel Díaz‐Gaxiola, Carmen Valenzuela, Marcelo García‐Guerrero   +4 more
openalex   +1 more source

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

Molecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat, Marc Arbyn, David Baldwin, Xavier Castells, Solveig Hofvind, Urska Ivanus, Carlo Senore, Esther Toes‐Zoutendijk, Carlijn van der Aalst, Carlos Canelo‐Aybar, Fiorella Karina Fernández‐Sáenz, Ariadna Feliu, Hajo Zeeb, Andre L. Carvalho, Erica D'Souza, David Ritchie, Carolina Espina, Iris Lansdorp‐Vogelaar, Andrea DeCensi   +18 more
wiley   +1 more source

Hematopoietic growth factors in rheumatoid arthritis: A critical approach to their use in view of possible adverse effects

, 1993
Michael H. Ellman, Margaret Telfer, Arnold F. Turner   +2 more
openalex   +1 more source