Results 231 to 240 of about 16,071,502 (380)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

GABARAPL2 Is Critical for Growth Restriction of Toxoplasma gondii in HeLa Cells Treated with Gamma Interferon

, 2020
Zhaoxia Zhang, Haorong Gu, Qi Li, Jun Zheng, Shinuo Cao, Changjiang Weng, Honglin Jia   +6 more
openalex   +2 more sources

Catalysts and inhibitors of critical transitions in ecological systems. [PDF]

Proc Natl Acad Sci U S A
Yang Y, Barabás G, Saavedra S, Li A.
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Existence results for nonlinear Schrodinger equations involving the fractional (p,q)-Laplacian and critical nonlinearities

Electronic Journal of Differential Equations, 2021
Huilin Lv, Shenzhou Zheng, Zhaosheng Feng   +2 more
doaj  

Urethral Reconstruction of Critical Defects in Rabbits Using Molecularly Defined Tubular Type I Collagen Biomatrices: Key Issues in Growth Factor Addition

, 2010
Jody Nuininga, Martin J.W. Koens, Dorien M. Tiemessen, Egbert Oosterwijk, Willeke F. Daamen, Paul J. Geutjes, Toin H. Van Kuppevelt, Wout Feitz   +7 more
openalex   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Elucidating the roles of essential genes in autotrophic metabolism and cell morphology of Clostridium ljungdahlii by CRISPRi. [PDF]

Appl Microbiol Biotechnol
Munir S, Wan S, Gao X, Lai M, Mu Z, Wang H, Liu Z, Li F, Xia L, Tan Y.   +9 more
europepmc   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Physics of sub-critical crack growth in a fibrous material: experiments and model

, 2005
Stéphane Santucci, Cortet, Pierre-Philippe, Loïc Vanel, S. Ciliberto   +3 more
openalex   +1 more source