Results 291 to 300 of about 16,071,502 (380)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Optimizing nitrogen and sulfur supplementation for enhanced growth and biochemical composition in Solanum lycopersicum under hydroponic conditions. [PDF]

Sci Rep
Anjum MA, Hosen ME, Sraboni FS, Ahmed NU, Goshwami A, Islam MA, Acharjee UK, Alqahtani T, Sindi ER, Tóth Z, Zaman R, Zaki MEA.   +11 more
europepmc   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

De novo nucleotide biosynthesis and its dynamic regulation are crucial for systemic infection by extraintestinal Escherichia coli. [PDF]

PLoS Pathog
Zhang C, Yang Y, Wang S, Liu Y, Zhao X, Yin F, Hu Y, Xue Y, Bu Z, Li S, Tan C, Zhou R, Huang Q.   +12 more
europepmc   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Looking Back with Gratitude: An Editor's Reflection on 6 Years of Successes, Challenges, and Growth. [PDF]

Ann Am Thorac Soc
Cooke CR.
europepmc   +1 more source

Enhancement of Apiaceae pre-germination embryo growth, mericarp ageing resilience and germination differs between hormone, gas plasma, and hydropriming technologies. [PDF]

Planta
Fatelnig LMM, Walker M, Grainge G, Hourston JE, Kennedy S, Široká J, Novák O, Tarkowská D, Strnad M, Nakabayashi K, Steinbrecher T, Leubner-Metzger G.   +11 more
europepmc   +1 more source

Mapping the Functional Epitopes of Human Growth Hormone: Integrating Structural and Evolutionary Data with Clinical Variants. [PDF]

Curr Issues Mol Biol
Verma S, Pandey AV.
europepmc   +1 more source

PUBLIC EDUCATIONAL INVESTMENT AND ECONOMIC GROWTH IN NIGERIA: A CRITICAL ANALYSIS

Graham-Kingsley Gift I., PhD, Dr. Graham-Kingsley Gift I., PhD, EKE PROMISE, PhD, Dr. EKE PROMISE, PhD   +1 more
openalex   +1 more source