Results 31 to 40 of about 153,489 (223)

Heat Transfer Characteristics and Prediction Model of Supercritical Carbon Dioxide (SC-CO2) in a Vertical Tube

Energies, 2017
Due to its distinct capability to improve the efficiency of shale gas production, supercritical carbon dioxide (SC-CO2) fracturing has attracted increased attention in recent years. Heat transfer occurs in the transportation and fracture processes.
Can Cai, Xiaochuan Wang, Shaohua Mao, Yong Kang, Yiyuan Lu, Xiangdong Han, Wenchuan Liu   +6 more
doaj   +1 more source

Heat Sink Design for WBG Power Modules Based on Fourier Series and Evolutionary Multi-Objective Multi-Physics Optimization

IEEE Open Journal of Power Electronics, 2021
Optimal heat dissipation in power modules can significantly increase their power density. Removing the generated heat is critical for capturing the benefits of advanced semiconductor materials and improving the reliability of the device operation.
Emre Gurpinar, Raj Sahu, Burak Ozpineci
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Control of lithospheric to crustal fault architecture on Cenozoic Rift geothermal systems (Upper Rhine, Bresse and Limagne, France)

BSGF - Earth Sciences Bulletin
Hydrothermal groundwater systems are key to renewable energy due to their high thermal efficiency. Effective geothermal resources require not only a heat source but also permeable geological formations and appropriate flow patterns.
Aubert Irène, Vennin Emmanuelle, Kaci Tassadit, Pellenard Pierre, Morales Chloé, Collin Pierre-Yves, Guiraud Michel   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Characteristics of heat transfer under boiling refrigerant transition by pool boiling of immiscible mixtures (Effects of the height of more-volatile liquid layer)

Nihon Kikai Gakkai ronbunshu, 2019
Boiling heat transfer using immiscible liquid mixtures is an innovative cooling technique for high-heat-density electronic devices. Immiscible liquid mixtures which are composed of more-volatile liquid with higher density and less-volatile liquid with ...
Osamu KAWANAMI, Yasuhiko HARA, Naohisa TAKAGAKI, Itsuro HONDA   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

THEORETICAL CALCULATION METHOD FOR POWDER CAPILLARY STRUCTURE OF LOOP HEAT PIPE WITH INVERTED MENISCUS

Наука и техника, 2011
Organization of heat exchange in the evaporator of a loop heat pipe (LHP) by the principle of inverted menisci is connected with considerable non-uniformity of heat flow on an evaporating surface that reduces LHP operating characteristics.
A. V. Ageenko, V. V. Maziuk
doaj