Results 51 to 60 of about 20,381,842 (254)

Typical ophthalmic critical information systems

Офтальмохирургия, 2022
Relevance. According to the law « the security of critical information infrastructure of the Russian Federation» 26.07.2017 No. 187-FZ information systems used in ophthalmology can be classified as significant objects of critical information ...
A.V. Krasov, N.N. Lansere, I.I. Fadeev, A.M. Gelfand, M.V. Lesnevskii   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

MANAGING THE SECURITY OF GOVERNMENT INFORMATION SYSTEMS AS CRITICAL INFORMATION INFRASTRUCTURE OBJECTS

Безопасность информационных технологий
The article aims to systematize the protection requirements for state information systems (SIS) as critical information infrastructure (CII) objects and measures of improving their resilience to cyber threats.
Grigory P. Gavdan, Artyom A. Golubev, Artur G. Golubev, Igor Y. Zhukov, Alina P. Rybalko   +4 more
doaj   +1 more source

Key Problems of the Critical Information Infrastructure through Scada Systems Research

Информатика и автоматизация, 2019
In the current age, cyber security is an essential element of any information system. A key aspect is in the critical information infrastructure, where information security has become a top priority for information and network security experts.
Georgi Rumenov Tsochev, Radoslav Dakov Yoshinov, Oleg Petrov Iliev   +2 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Internet of Things Security in Critical Information Infrastructure: Trends and Prospects [PDF]

中国工程科学
As the Internet of Things (IoT) in critical information infrastructure rapidly scales up, its widespread deployment in sectors such as energy, transportation, and industry is introducing unprecedented security challenges.
Wenyuan Xu, Yushi Cheng, Yanjiao Chen, Xiaoyu Ji   +3 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Digital engineering for resilient road infrastructure outcomes: Evaluating critical asset information requirements

Journal of Sustainable Development of Energy, Water and Environment Systems, 2022
The United Nations Sustainable Development Goal 9 on building resilient infrastructure highlights the urgent need for enabling evidence-based decision making for Infrastructure Asset Management supported by targeted platforms such as digital engineering ...
Savindi Caldera, Sherif Mohamed, Sherif Mostafa, Cheryl Desha   +3 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source