Results 51 to 60 of about 1,558,786 (324)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Determinants of Critical Infrastructure Resources
Foundations of Management, 2017 This article is devoted to the issue of how resources are interpreted in the form of technology reactors that, as a result of unexpected circumstances, turn into pyramidal or avalanche threat dynamics.
Ostrowska Teresa, Krupa Tadeusz
doaj +1 more source
Identifying critical elements of road infrastructure using cascading impact assessment
Transport, 2020 Road transport is a key means of transporting people and cargo on land. Its particular advantages are speed and operability, which are balanced, however, by dependence on road infrastructure.
David Rehak +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
3D sensors in critical infrastructure
MATEC Web of Conferences, 2018 The danger of terrorism is a result of the increased risk of critical infrastructure. We will focus on enumerating each area then listing of possible real uses in security and protection and finally we will focus in the list of used 3D sensors (in ...
Miroslav Marcanik +2 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The terrorist threat to critical infrastructure from the perspective of criminal risk
Bulletin of "Carol I" National Defense UniversityThe field of critical infrastructure protection emerged as part of the fight against terrorism. Although a transition to an all-hazards approach has taken place, terrorism remains a significant threat to entities providing essential services. The relief
Sorina-Denisa POTCOVARU
doaj +1 more source
Przegląd Zachodniopomorski, 2020 Electricity grids failures, caused by the natural forces, occur often locally and can be handled by the grid’s operator services. If, however, a large number of elements are damaged over a vast area, a large territory is devoid of power supply.
Ewelina Kochanek
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Commercial critical systems and critical infrastructure protection : a future research agenda [PDF]
, 2007 Secure management of Australia’s commercial critical infrastructure presents ongoing challenges to owners and the government. Although it is currently managed through high-level information sharing via collaboration, but does this suit the ...
Leitch, Shona, Warren, Matthew
core +1 more source