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Critical limb ischemia

Internal and Emergency Medicine, 2011
Critical limb ischemia (CLI) represents the most advanced clinical stage of peripheral arterial disease. It is usually caused by obstructive atherosclerotic arterial disease and is associated with very high morbidity and mortality. The pathophysiology of CLI is a complex and chronic process affecting the macrovascular and microvascular circulation of ...
GRESELE, Paolo   +2 more
openaire   +4 more sources

Hydrogel Loaded with VEGF/TFEB‐Engineered Extracellular Vesicles for Rescuing Critical Limb Ischemia by a Dual‐Pathway Activation Strategy

Advanced Healthcare Materials, 2021
Critical limb ischemia (CLI) is the most severe clinical manifestation of peripheral arterial disease, which causes many amputations and deaths. Conventional treatment strategies for CLI (e.g., stent implantation and vascular surgery) bring surgical risk,
Zheng Xing   +9 more
semanticscholar   +1 more source

Critical limb ischemia

Current Treatment Options in Cardiovascular Medicine, 2001
Patients with critical limb ischemia (CLI) present with ischemic rest pain or with tissue loss. Tissue loss, in its mildest presentation, includes focal ischemic ulceration or nonhealing wounds. Gangrene is the manifestation of severe chronic ischemia.
David L., Dawson, Ryan T., Hagino
openaire   +3 more sources

Calcium Score Predicts Mortality After Revascularization in Critical Limb Ischemia

Journal of Endovascular Therapy, 2021
Purpose: The calcium score is a measure of vessel wall calcification and has clinical applications when studied in different vascular beds. The presence of vascular calcification in the arteries of the lower limbs is very common in patients with ...
A. Megale   +8 more
semanticscholar   +1 more source

Critical Limb Ischemia

Annals of Vascular Surgery, 2000
Critical limb ischemia (CLI) is defined as a condition that endangers all or part of the limb if no radical improvement in blood flow can be achieved by means of surgery, interventional radiology, or medical treatment163 (Figure 42.1).
Leonella Pasqualini, Elmo Mannarino
openaire   +2 more sources

Critical limb ischemia

Current Treatment Options in Cardiovascular Medicine, 2007
Critical limb ischemia (CLI) is the most severe manifestation of peripheral artery disease (PAD). Without timely recognition, appropriate diagnosis, and revascularization, patients with CLI are at risk for amputation or potentially fatal complications.
David L, Dawson, Joseph L, Mills
openaire   +2 more sources

Critical Limb Ischemia

Cardiology Clinics, 2015
Critical limb ischemia (CLI), the most advanced form of peripheral artery disease (PAD), carries grave implications with regard to morbidity and mortality. Within 1 year of CLI diagnosis, 40% to 50% of diabetics will experience an amputation, and 20% to 25% will die. Management is optimally directed at increasing blood flow to the affected extremity to
Sarah, Elsayed, Leonardo C, Clavijo
openaire   +2 more sources

Statin therapy for reduction of cardiovascular and limb-related events in critical limb ischemia: A systematic review and meta-analysis

Vascular Medicine, 2020
High-intensity statins are recommended for patients with peripheral artery disease (PAD). Critical limb ischemia (CLI) is the most advanced presentation of PAD. The benefit of statins in the CLI population is unclear based on the existent studies.
D. Kokkinidis   +10 more
semanticscholar   +1 more source

Critical Limb Ischemia

2017
Patients with CLI have a poor prognosis, the estimated 3-year probability of mortality being 35.1%. As a result, preference to less burdensome endovascular treatment should be given, provided the same levels of symptomatic improvement can be achieved as with open surgery.
Suparna Rao   +2 more
  +4 more sources

Understanding critical limb ischemia

Nursing, 2008
Find out how to halt this progression of peripheral arterial disease before it jeopardizes life and limb.
openaire   +3 more sources

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