Results 241 to 250 of about 10,947,423 (301)

Treatment failure and associated factors among people living with HIV on second-line antiretroviral therapy in Zambia. [PDF]

Int Health
Sikambale K, Chanda C, Daka V, Kazonga E, Mudenda S.   +4 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Application of a Pediatric Tracheostomy-Specific Risk Tier System Using Administrative Data.

JAMA Otolaryngol Head Neck Surg
Johnson RF, Zaniletti I, Wang CS, Kou YF, Chorney SR.   +4 more
europepmc   +1 more source

A Review of Machine Learning and AI Applications in Enhancing HACCP Systems for Ice Cream Manufacturing. [PDF]

Foods
Gaona Hernandez JP, Olapade GM, Cho HS, Jung HM, Lee MH, Lee WY.   +5 more
europepmc   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Protocol for live-imaging of blood flow and vascular permeability in zebrafish larvae. [PDF]

STAR Protoc
Rajamannar P, Levkowitz G.
europepmc   +1 more source

Three-Dimensional Perspective on Scar-Related Ventricular Tachycardia Substrate: Critical Conduction Abnormalities as Ablation Targets and Implications for Procedural Endpoints. [PDF]

Rev Cardiovasc Med
Komatsu Y, Nogami A.
europepmc   +1 more source

The Association of Hospital Characteristics With Medicaid Managed Care Hospital Prices. [PDF]

Health Serv Res
Alfrey B, Ukert B, Gordon AS.
europepmc   +1 more source

Macromolecular association creates dispersity of components that determines liquid-liquid phase separation of oppositely charged polyions. [PDF]

Proc Natl Acad Sci U S A
Ballauff M, Tirrell M.
europepmc   +1 more source

Short-Term Exposure to PM2.5 and Emergency Department Visits for Asthma and Chronic Obstructive Pulmonary Disease.

JAMA Netw Open
Kulkarni A, Okada Y, Aik J, Siddiqui FJ, Koh MS, Hughes F, Ohnuma T, Krishnamoorthy V, Ong MEH.   +8 more
europepmc   +1 more source