Results 141 to 150 of about 424,711 (307)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
International Journal of Critical Diversity StudiesDespite increased interest in advancing diversity, equity and inclusion (DEI), progress in committing to its goals remains slow. Significant gaps persist in parity across gender, race/ethnicity, physical and mental ability, age and other diversity ...
Ekaterina Zibrova
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Critical metrics of eigenvalue functionals via Clarke subdifferential [PDF]
We set up a new framework to study critical points of functionals defined as combinations of eigenvalues of operators with respect to a given set of parameters: Riemannian metrics, potentials, etc.
Petrides, Romain, Tewodrose, David
core +1 more source
Development of performance and error metrics for ultrasound-guided axillary brachial plexus block [PDF]
, 2017 Osman M Ahmed,1 Brian D O’Donnell,1,2 Anthony G Gallagher,2 George D Shorten1,2 1Department of Anaesthesia and Intensive Care, University College Cork and Cork University Hospital, 2The ASSERT Center, University College Cork, Cork, Ireland Purpose:
Shorten GD +3 more
core
Soil health metrics for assessment of floodplain restorations
Environmental Research LettersWhile healthy soils are critical for stream and floodplain restoration, little guidance is available to restoration practitioners on which soil metrics to measure and when to expect the signs of recovery post-restoration.
Joseph George Galella +9 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Insights into ImagingRadiomics research has been hindered by inconsistent and often poor methodological quality, limiting its potential for clinical translation. To address this challenge, the METhodological RadiomICs Score (METRICS) was recently introduced as a tool for ...
Burak Kocak +18 more
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source