Results 131 to 140 of about 424,711 (307)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Research assessment. New metrics? More metrics? No metrics? [PDF]
, 2018 Trabajo presentado al EuroScience Open Forum (ESOF), celebrado en Manchester (UK) del 23 al 27 de julio de 2016.Research assessment is critical for allowing decision makers, from peer reviewers to politicians and the science-led public, to identify ...
Rafols, Ismael
core
DronesFlapping-wing micro air vehicles (FWMAVs) have gained increasing attention due to their manoeuvrability, low acoustic signature, and suitability for confined or cluttered environments.
Sebastian Valencia +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Critical Infrastructure Protection Metrics and Tools; The Mathematics of Terrorism Risk [June 5-7, 2008] [video] [PDF]
, 2008 Presented at Critical Infrastructure Protection Workshop: Metrics and Tools; 5-7 June 2008This video is of Michael Powers' presentation for the Critical Infrastructure Protection: Metrics and Tools workshop; the presentation is titled: The Mathematics of
Powers, Michael
core
Heavy-Tail Analysis of Network Theory-Based Critical Asset Identification Metrics for Bulk Transmission Power Systems [PDF]
, 2020 Large-scale blackouts present a significant threat to the reliable delivery of electricity expected of utilities. Often these blackouts are precipitated on a small set of failures, whether through component failures or operator error as a result of ...
Bittenbender, Erick K.
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Continuously monitoring shoulder motion after total shoulder arthroplasty: maximum elevation and time spent above 90° of elevation are critical metrics to monitor. [PDF]
J Shoulder Elbow Surg, 2019 Chapman RM +3 more
europepmc +1 more source