Results 111 to 120 of about 424,711 (307)

Critical associated metrics on contact manifolds [PDF]

open access: yesJournal of the Australian Mathematical Society. Series A. Pure Mathematics and Statistics, 1984
AbstractDefining a function on the set of all Riemannian metrics associated to a contact form on a compact manifold by taking the integral of the Ricci curvature in the direction of the characteristic vector field, it is shown that on a compact regular contact manifold the only critical points of this function are the metrics for which the ...
openaire   +2 more sources

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

open access: yesFEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino   +2 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A Multidimensional Correlation Analysis Framework of SAR Target Recognition-Oriented Image Quality Enhancement

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Synthetic aperture radar (SAR) possesses significant advantages in automatic target recognition (ATR) due to its all-weather, day–night imaging capabilities. However, SAR-ATR faces complex challenges from inherent speckle noise and imaging-induced
Chengyu Wan   +5 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Critical Infrastructure Protection Metrics and Tools [June 5-7, 2008] [PDF]

open access: yes, 2008
The article of record may be found here: http://www.hsdl.org/?view&did=704476This is the main page for the Critical Infrastructure Protection: Metrics and Tools workshop held June 5-7, 2008.

core  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Subjective Validity of Figures of Merit for Room Aspect Ratio Design [PDF]

open access: yes, 2009
Attempts have long been made to classify a room's low frequency audio reproduction capability with regards to its aspect ratio. Common metrics used have relied on the homogeneous distribution of modal frequencies and from these a number of 'optimal ...
Wankling, Matthew, Fazenda, Bruno
core  

METrICS: a Measurement Environment For Multi-Core Time Critical Systems [PDF]

open access: yes, 2018
International audienceWith the upcoming shift from single-core to multi-core COTS processor for safety critical products such as avionics, railway or space computer subsystems, the safety critical industry is facing a trade-off in term of performance ...
Girbal, Sylvain   +2 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

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