Results 91 to 100 of about 1,099,145 (281)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Single-Inhaler Triple Therapy in Primary Care Across Europe: Expert Panel Consensus on the Consequences of Payer-Driven Access Rules and Call to Action

International Journal of COPD
Fabiano Di Marco,1 Orjola Shahaj,2 Arschang Valipour,3 Bertrand Legrand,4 Claudio Jommi,5 Claudio Micheletto,6 Claus Franz Vogelmeier,7 Daryl Freeman,8 Janwillem WH Kocks,9 Luis Alves,10 Myriam Calle Rubio,11 Rudi Peché,12 Susanna Palkonen Snr,13 Tonya ...
Di Marco F, Shahaj O, Valipour A, Legrand B, Jommi C, Micheletto C, Vogelmeier CF, Freeman D, Kocks JWH, Alves L, Rubio MC, Peché R, Palkonen Snr S, Winders T, Roche N   +14 more
doaj  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A Multidimensional Correlation Analysis Framework of SAR Target Recognition-Oriented Image Quality Enhancement

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Synthetic aperture radar (SAR) possesses significant advantages in automatic target recognition (ATR) due to its all-weather, day–night imaging capabilities. However, SAR-ATR faces complex challenges from inherent speckle noise and imaging-induced
Chengyu Wan, Siqian Zhang, Zilong Chen, Yang Chen, Boli Xiong, Gangyao Kuang   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Critical associated metrics on contact manifolds [PDF]

Journal of the Australian Mathematical Society. Series A. Pure Mathematics and Statistics, 1984
AbstractDefining a function on the set of all Riemannian metrics associated to a contact form on a compact manifold by taking the integral of the Ricci curvature in the direction of the characteristic vector field, it is shown that on a compact regular contact manifold the only critical points of this function are the metrics for which the ...
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

H-functional and Matsushima type decomposition theorem

, 2019
The H-functional characterizes K\"ahler-Ricci solitons as its critical points, and also plays an important role of the existence problem for K\"ahler-Einstein metrics. In this paper we prove the Hessian formula for the H-functional at its critical points,
Nakamura, Satoshi
core