Results 81 to 90 of about 424,711 (307)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
A goals/questions/metrics plan for monitoring user involvement and participation in ERP (...) [PDF]
ERP implementation success is influenced by a large number of factors. User involvement and participation is one of the most cited critical success factors in ERP implementation projects, and one of the most critical ones for their satisfactory outcome ...
JOSE MANUEL ESTEVES
core
Do Resilience Metrics of Water Distribution Systems Really Assess Resilience? A Critical Review [PDF]
, 2023 Having become vital to satisfying basic human needs, water distribution systems (WDSs) are considered critical infrastructure. They are vulnerable to critical events such as extreme weather, natural and man-made disasters, armed conflicts etc. To account
Leštáková, Michaela +4 more
core
Applied Biodiversity Metrics; Concepts to Choose Them Well
DiversityThe evaluation of biodiversity is an essential tool for conservation, management of natural resources, and assessment of ecosystem functioning. Choosing an appropriate and understandable diversity metric is critical to ultimately make better decisions ...
Marie-Ève Roy +2 more
doaj +1 more source
Metrics of Arterial Hyperoxia and Associated Outcomes in Critical Care*
Critical Care Medicine, 2017 Objective:Emerging evidence has shown the potential risks of arterial hyperoxia, but the lack of a clinical definition and methodologic limitations hamper the interpretation and clinical relevance of previous studies. Our purpose was to evaluate previously used and newly constructed metrics of arterial hyperoxia and systematically assess their ...
Helmerhorst, H.J.F. +6 more
openaire +3 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Otherwise Engaged: Social Media from Vanity Metrics to Critical Analytics [PDF]
, 2018 Vanity metrics is a term that captures the measurement and display of how well one is doing in the “success theater” of social media. The notion of vanity metrics implies a critique of metrics concerning both the object of measurement as well as their ...
Rogers, R.; id_orcid, Rogers, R.
core +2 more sources
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
Applicability of Structural Code Coverage Metrics for Safety-Critical Systems [PDF]
, 2010 This presentation gives an overview on structural code coverage metrics and demonstrates the applicability of these metrics for safety-critical systems regarding the fault-dectection capability and the remaining undetected faults ...
Kandl, Susanne
core
Evaluation of ventricular–vascular coupling with critical care metrics: An in silico approach
Physiological ReportsMean arterial pressure and cardiac output provide insufficient guidance for the management of intraoperative hypotension (IOH). In silico models offer additional insights into acute changes in hemodynamic parameters that may be encountered during IOH.
Lawrence J. Mulligan +7 more
doaj +1 more source