Results 61 to 70 of about 437,756 (218)

Single-Inhaler Triple Therapy in Primary Care Across Europe: Expert Panel Consensus on the Consequences of Payer-Driven Access Rules and Call to Action

International Journal of COPD
Fabiano Di Marco,1 Orjola Shahaj,2 Arschang Valipour,3 Bertrand Legrand,4 Claudio Jommi,5 Claudio Micheletto,6 Claus Franz Vogelmeier,7 Daryl Freeman,8 Janwillem WH Kocks,9 Luis Alves,10 Myriam Calle Rubio,11 Rudi Peché,12 Susanna Palkonen Snr,13 Tonya ...
Di Marco F, Shahaj O, Valipour A, Legrand B, Jommi C, Micheletto C, Vogelmeier CF, Freeman D, Kocks JWH, Alves L, Rubio MC, Peché R, Palkonen Snr S, Winders T, Roche N   +14 more
doaj  

Spontaneously interacting qubits from Gauss-Bonnet

Journal of High Energy Physics
Building on previous constructions examining how a collection of small, locally interacting quantum systems might emerge via spontaneous symmetry breaking from a single-particle system of high dimension, we consider a larger family of geometric loss ...
Sean Prudhoe, Rishabh Kumar, Sarah Shandera   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Integrating diversity and agency into social-ecological resilience metrics

Ecology and Society
Resilience is an increasingly popular concept in research and practice, but quantitative resilience analyses are often disconnected from resilience theory.
Vitor Hirata Sanches, Rubi Quiñones, Jonathan Vivas, Joseph H. A. Guillaume, Takuya Iwanaga, Jan H Kwakkel, Allyson E. Quinlan, Juan C. Rocha, Anne-Sophie Crépin, Vasilis Dakos, Jonathan F. Donges, Steven J. Lade   +11 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Evaluation of Systematic and Random Errors in Occupancy Grid Maps [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Map evaluation for occupancy grid mapping (OGM) is critical in the field of high-definition mapping of the road environment for autonomous vehicles. Existing methods cannot adequately evaluate the systematic and random errors that might be present in OGM.
Y. Liu, M. Radanovic, K. A. Ehinger, K. Khoshelham   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evaluating User Experience of SITASI System using HEART Metrics and Importance-Performance Analysis (IPA)

Edumatic
SITASI is a web-based system developed to help students manage references and citations for their final projects. Despite its importance, no comprehensive evaluation of the system’s user experience (UX) had been conducted. This study aims to evaluate the
Elsa Harmaniola, Tengku Khairil Ahsyar, Syaifullah Syaifullah, Anofrizen Anofrizen, Arif Marsal   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source