Results 101 to 110 of about 1,099,145 (281)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Under- and over-segmentation: New metrics for image segmentation accuracy measurement

Array
Image segmentation is a cornerstone of computer vision, with critical applications in medicine, autonomous vehicles, and agriculture. Despite advancements in deep learning-based segmentation, existing evaluation metrics (e.g., pixel accuracy, dice ...
Mobin Mohammadi, Kaveh Mollazade, Nasser Behroozi-Khazaei   +2 more
doaj   +1 more source

New Metrics from Polysomnography: Precision Medicine for OSA Interventions

Nature and Science of Sleep, 2023
Junwei Guo, Yi Xiao Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Yi Xiao, Department of
Guo J, Xiao Y
doaj  

On the existence of critical compatible metrics on contact 3‐manifolds

Bulletin of the London Mathematical Society
AbstractWe disprove the generalized Chern–Hamilton conjecture on the existence of critical compatible metrics on contact 3‐manifolds. More precisely, we show that a contact 3‐manifold admits a critical compatible metric for the Chern–Hamilton energy functional if and only if it is Sasakian or its associated Reeb flow is ‐conjugate to an algebraic ...
Y. Mitsumatsu, D. Peralta‐Salas, R. Slobodeanu   +2 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

How accurate are ChatGPT-4 responses in chronic urticaria? A critical analysis with information quality metrics

World Allergy Organization Journal
Background: The increasing use of artificial intelligence (AI) in healthcare, especially in delivering medical information, prompts concerns over the reliability and accuracy of AI-generated responses.
Ivan Cherrez-Ojeda, Ph.D.(c), Marco Faytong-Haro, Ph.D.(c), Patricio Alvarez-Muñoz, Ph.D., José Ignacio Larco, MD, Erika de Arruda Chaves, MD, Isabel Rojo, MD, Carol Vivian Moncayo, MD, German D. Ramon, MD, Gabriela Rodas-Valero, MD, Emek Kocatürk, MD, Giselle S. Mosnaim, MD, Karla Robles-Velasco, MD   +11 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source