Results 101 to 110 of about 29,068 (249)

Detergent Virus Inactivation in Chromatography Systems

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Detergent treatment is a widely utilized virus‐inactivation step in therapeutic protein manufacturing to safeguard products. Traditionally, this operation is performed in an incubation vessel in batch mode. In this investigation, a methodology was developed to enable virus inactivation via a post‐load, detergent‐containing wash within a bind ...
Kang Cai, Etienne Utiger, Chris Afdahl, Rayan Zamat, Jennifer Anderson, Yeldys De Armas, Gisela Ferreira   +6 more
wiley   +1 more source

Design Space Assessment of Virus Inactivation in Plasma‐Derived Matrices Establishes a Single Detergent Alternative to TX‐100‐Containing Mixes

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The detergent Triton X‐100 (TX‐100) is a typical component of solvent/detergent (S/D) mixes applied for virus inactivation steps of biomanufacturing processes, yet environmentally unfavorable properties have led to restrictions on its use. Deviron 13‐S9 has recently been described as an eco‐friendly TX‐100 alternative, with powerful virus ...
Johanna Kindermann, Cecilie Klausen, Michael Karbiener, Thomas R. Kreil   +3 more
wiley   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Micellisation behavior on the dodecyltrimethylammonium bromide in the presence of Brij-35 in pure water by conductivity measurement

Bibechana, 2017
Conductivity measurement of dodecyltrimethylammonium bromide in the presence of Brij-35 in aqueous media at 289.15 K is performed. The result showed a sharp increase in conductivity with increase in the concentration of dodecyltrimethylammonium bromide ...
Neelam Shahi, Ajaya Bhattarai
doaj  

Understanding cationic polyelectrolyte thermogels with varying charge densities toward biomaterials design

BMEMat, EarlyView.
Cationic polyurethane thermogels with customizable charge density were developed, exhibiting enhanced pH‐responsiveness. This work elucidates how cationic charges influence self‐assembly and thermogelling, providing insights for designing smart biomaterials.
Belynn Sim, Yi Jing Wong, Hamzah Kamaruddin, Qianyu Lin, Pablo Mota‐Santiago, Nigel Kirby, Alexis Lee, Yihao Leow, Alice Anhan Chen, Rubayn Goh, Xian Jun Loh   +10 more
wiley   +1 more source

Influence factors on the critical micelle concentration determination using pyrene as a probe and a simple method of preparing samples. [PDF]

R Soc Open Sci, 2020
Li H, Hu D, Liang F, Huang X, Zhu Q.
europepmc   +1 more source

DETERMINATION OF THE CRITICAL MICELLE CONCENTRATION IN SURFACTANT SOLUTIONS

Advances in Science and Environment
This study investigates the determination of the critical micelle concentration (CMC) and cloud point of synthesized surfactants, which are key parameters governing their physicochemical behavior in aqueous solutions. Surfactants, due to their amphiphilic nature, exhibit the ability to reduce surface tension and form micelles beyond a certain ...
Abdurahimova Madina, Boltaeva Gulsanam, Abdikamalova Aziza   +2 more
openaire   +1 more source

Drug‐coated balloons: From conventional designs to next‐generation innovations in vascular therapy

BMEMat, EarlyView.
This review traces the evolution of drug‐coated balloons (DCBs) from conventional designs to next‐generation platforms. We highlight innovations in balloon engineering, coating technologies, and therapeutic agents that enhance localized drug delivery while addressing challenges in efficiency, safety, and biocompatibility for vascular and emerging non ...
Lu Zhang, Jiawei Cui, Jin Wang, Manfred F. Maitz, Rifang Luo, Yunbing Wang   +5 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Global Trends and Advances in Traumatic Brain Injury

Brain Health, EarlyView.
ABSTRACT Traumatic brain injury (TBI) remains a major global public health challenge, contributing substantially to morbidity and mortality while imposing a significant socioeconomic burden. In recent years, notable progress has been made in understanding TBI pathophysiology, classification, monitoring, and treatment.
Yuan Zhuang, Xixian Liao, Jiyao Jiang, Guoyi Gao   +3 more
wiley   +1 more source