Results 31 to 40 of about 272,357 (265)

METHODS AND TECHNIQUES REGARDING THE GENERAL TECHNICAL-ECONOMIC IMPROVEMENT OF THE PLANTS [PDF]

open access: yesScientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2013
The capacity of continuous modernisation of our agriculture, in order to obtain some high vegetal and animal productions is reflected first of all by the effects of applying some productions technologies that are as adequate as possible to the natural ...
Georgiana CRUDU
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Application of Fuzzy theory to project scheduling with critical path method

open access: yesJournal of Applied Sciences and Environmental Management, 2013
In this paper, we analyze the project scheduling problem using fuzzy theory. The crisp activity durations are modeled as triangular fuzzy sets. Fuzzy forward pass was carried out to determine fuzzy activity earliest start, fuzzy event earliest time and ...
MH Oladeinde, DO Itsisor
doaj   +3 more sources

Schedula Anima: Dynamic Visualization of Gantt Charts and Resource Usage Graphs in Project Scheduling

open access: yesBuildings
Scheduling is essential in managing projects. ‘Schedula Anima’ is a new software designed to provide a comprehensive view of schedules between early and late dates for construction project managers.
Alexander Maravas   +1 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Method for reducing cloud workflow completion time under the task interruption

open access: yes网络与信息安全学报, 2020
As more and more large-scale scientific workflows are delivered to clouds, the business model of workflow-as-a-service is emerging. But there are many kinds of threats in the cloud environment, which can interrupt the task execution and extend the ...
Yawen WANG, Yunfei GUO, Wenyan LIU, Shumin HUO
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

PENERAPAN CRITICAL PATH METHOD (CPM) DALAM MENGANALISIS MANAJEMEN WAKTU PADA PERENCANAAN IKLAN GMS DIGITAL MARKETING

open access: yesJurnal Lebesgue
Planning helps monitor activities. to achieve the expected efficiency and effectiveness. In advertising planning at GMS Digital Marketing, there are often losses. The purpose of this study is to find out how to manage good time in advertising planning in
Mayang Modelina Cynthia   +2 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

open access: yesFEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu   +5 more
wiley   +1 more source

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