Signaling Pathways Critical for Tooth Root Formation
, 2017 Tooth is made of an enamel-covered crown and a cementum-covered root. Studies on crown dentin formation have been a major focus in tooth development for several decades.
J. Wang, J.Q. Feng
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
IMG Journal: Critical Genealogies and Emerging Pathways in Image Research
img journalThis paper reflects on the first ten issues of IMG Journal – International and Interdisciplinary Journal on Image, Imagery and Imagination as a coherent intellectual project that has progressively articulated a critical genealogy of the image as a form ...
Alessandro Luigini
doaj +1 more source
Identification of Critical Pathways and Potential Key Genes in Poorly Differentiated Pancreatic Adenocarcinoma. [PDF]
Onco Targets Ther, 2021 Lu Y +10 more
europepmc +1 more source
Aligning modes of organization with technology: Critical transactions in the reform of infrastructures [PDF]
This paper is about the alignment of technology and modes of organization in infrastructures in the context of their reform. Since infrastructures are characterized by strong technical complementarities, we explore the resulting 'critical technical ...
John Groenewegen +2 more
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Angiogenesis-associated pathways play critical roles in neonatal sepsis outcomes
Scientific ReportsNeonatal sepsis is a major cause of childhood mortality. Limited diagnostic tools and mechanistic insights have hampered our abilities to develop prophylactic or therapeutic interventions.
Mario Fidanza +22 more
doaj +1 more source
Identification of critical pathways and potential therapeutic targets in poorly differentiated duodenal papilla adenocarcinoma. [PDF]
Cancer Cell Int, 2021 Lu Y +8 more
europepmc +1 more source
, 2016 Determining the fundamental architectural design of complex nervous systems will lead to significant medical and technological advances. Yet it remains unclear how nervous systems evolved highly efficient networks with near optimal sharing of pathways ...
Jaeseung Jeong (220472) +7 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source