Results 121 to 130 of about 6,548,421 (205)
Do critical pathways improve outcomes of patients with cardiac failure?
, 2011 Cardiac failure represents an important public health problem and despite recent clinical, diagnostic and therapeutic advances, the incidence and prevalence of this syndrome show a steady increase.
Faggian F +5 more
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Rodent models of Alzheimer's disease: Critical analysis of current hypotheses and pathways for future ...
C Culmsee (18842767) +15 more
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Critical misalignments in climate pledges reveal imbalanced sustainable development pathways
Nature CommunicationsWe explore the integration of climate action and Sustainable Development Goals (SDGs) in the first two submissions of nationally determined contributions (NDCs) using an AI-based, human-validated framework.
Francesca Larosa +7 more
doaj +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Women's recovery capital pathways
This book asks the question: what helps or hinders women’s recovery pathways? Women’s Recovery Capital Pathways brings the voices of fourteen women to the forefront, offering real lived insights of their power, strength and resiliency. It highlights that
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, 2014 Dr. Haibo Zeng has joined the Bradley Department of Electrical and Computer Engineering as an assistant professor. Zeng will work with the department’s Center for Embedded Systems for Critical Applications.
Virginia Tech. Center for Embedded Systems for Critical Applications
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Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source