Results 101 to 110 of about 1,573,391 (311)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Altered serum metabolome associated with vascular calcification developed from CKD and the critical pathways. [PDF]

Front Cardiovasc Med, 2023
Tan R, Ou S, Kang T, Wu W, Xiong L, Zhu T, Zhang L.   +6 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Protecting Critical Infrastructure by Identifying Pathways of Exposure to Risk [PDF]

Technology Innovation Management Review, 2013
Increasingly, our critical infrastructure is managed and controlled by computers and the information networks that connect them. Cyber-terrorists and other malicious actors understand the economic and social impact that a successful attack on these ...
Philip O’Neill
doaj  

Targeting critical pathways in ferroptosis and enhancing antitumor therapy of Platinum drugs for colorectal cancer. [PDF]

Sci Prog, 2023
Wang G, Wang JJ, Zhi-Min Z, Xu XN, Shi F, Fu XL.   +5 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Prehospital time efficiency in the Portuguese Stroke Fast-Track pathway: a nationwide observational study

Journal of Stroke and Cerebrovascular Diseases
Background: Timely prehospital management is critical to improve acute stroke outcomes by minimising time to reperfusion. Despite Stroke Fast-Track pathways, reductions in system response times remain limited. This study aimed to describe system response
Pedro Pires Lavinha, Diana Aguiar de Sousa, Baltazar Nunes, Paulo Boto   +3 more
doaj   +1 more source

Critical pathways for continuous quality improvement: a multicentric analysis on the management of patients with lung cancer in Italian best performing hospitals. [PDF]

J Prev Med Hyg, 2023
DE Belvis AG, Catalani MC, Morsella A, Sessa G, Palinuro A, Giubbini G, Watteble F, Angioletti C.   +7 more
europepmc   +1 more source

A comparison of critical thinking skills for hospitality management graduates from associate and baccalaureate degree programs [PDF]

, 2001
Plan BIt has been suggested that the university and college hospitality management programs must change their programs to meet the needs of the industry.
Oliver, Michael J.
core  

Putative adverse outcome pathways relevant to neurotoxicity

, 2015
The Adverse Outcome Pathway (AOP) framework provides a template that facilitates understanding of complex biological systems and the pathways of toxicity that result in adverse outcomes (AOs).
Crofton, KM, Behl, M, Lein, PJ, Sachana, M, Hargreaves, A, Louisse, J, Forsby, A,, Bal-Price, A, Landesmann, B, Shafer, TJ   +9 more
core   +1 more source