Results 101 to 110 of about 6,548,421 (205)
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Protecting Critical Infrastructure by Identifying Pathways of Exposure to Risk [PDF]
Technology Innovation Management Review, 2013 Increasingly, our critical infrastructure is managed and controlled by computers and the information networks that connect them. Cyber-terrorists and other malicious actors understand the economic and social impact that a successful attack on these ...
Philip O’Neill
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
IMG Journal: Critical Genealogies and Emerging Pathways in Image Research
img journalThis paper reflects on the first ten issues of IMG Journal – International and Interdisciplinary Journal on Image, Imagery and Imagination as a coherent intellectual project that has progressively articulated a critical genealogy of the image as a form ...
Alessandro Luigini
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
, 2012 European cities are becoming increasingly diverse. The aim of the ELITES, Pathways to Success projects is to explore today’s new (upcoming) elite in Europe’s large cities: successful entrepreneurs, people working in high-skilled jobs and in leadership ...
Lelie, F, Crul, MRJ, Schneider, J
core +1 more source
Successful School Leadership and Critical Pathways to Improve Student Learning
EncyclopediaSince the late 1970s, scholars began to develop effective school leadership models that enhance student achievement. Recent research over the past three decades has consistently shown that school leadership influences student learning mainly through ...
Jingping Sun
doaj +1 more source
, 2010 The Center for Embedded Systems for Critical Applications (CESCA) held its annual workshop titled “CESCA Day” at the Owens Banquet Hall in Blacksburg, Va., on May 6, 2010! Events included keynote, tutorials, poster sessions, and a student panel.
Virginia Tech. Center for Embedded Systems for Critical Applications
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source