pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Barriers to Electrification: Analyzing Critical Delays and Pathways Forward
World Electric Vehicle JournalThis paper extensively explores the intricate nuances surrounding the delayed transition to new business models for electric vehicles. While there is commendable clarity regarding stakeholders, model possibilities, emission-reduction strategies, state ...
Beatriz Amante García +1 more
doaj +1 more source
Identification of Potential Genes and Critical Pathways in Postoperative Recurrence of Crohn's Disease by Machine Learning And WGCNA Network Analysis. [PDF]
Curr Genomics, 2023 Rajalingam A, Sekar K, Ganjiwale A.
europepmc +1 more source
Reconnecting Youth through Dropout Reengagement Centers [PDF]
, 2013 Research shows that many out-of-school youth want to return to school, but are uncertain how to do so and are fearful they will not succeed once they get there.
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Altered serum metabolome associated with vascular calcification developed from CKD and the critical pathways. [PDF]
Front Cardiovasc Med, 2023 Tan R +6 more
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Targeting critical pathways in ferroptosis and enhancing antitumor therapy of Platinum drugs for colorectal cancer. [PDF]
Sci Prog, 2023 Wang G +5 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Protecting Critical Infrastructure by Identifying Pathways of Exposure to Risk [PDF]
Technology Innovation Management Review, 2013 Increasingly, our critical infrastructure is managed and controlled by computers and the information networks that connect them. Cyber-terrorists and other malicious actors understand the economic and social impact that a successful attack on these ...
Philip O’Neill
doaj