Results 81 to 90 of about 1,573,391 (311)

More through the door: increasing entry to university geoscience education as a means to address the critical minerals skills shortage

Earth Science, Systems and Society
Critical minerals (CMs) supply is vulnerable to a skills shortage. We focus on (1) the UK situation, where suitable training is provided but numbers taking the university courses have dwindled, and (2) routes through geoscience education into CM careers,
K.R. Moore, K.M. Ryan, F. Wall, R.K. Shail, P.J. Foster   +4 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Implementation and use of technology-enabled remote monitoring for chronic obstructive pulmonary disease: a rapid qualitative evaluation

Health and Social Care Delivery Research
Background Chronic obstructive pulmonary disease affects around 2% United Kingdom population. Timely identification of patients at risk of deterioration is crucial.
Nikki Newhouse, Agne Ulyte, Zuzanna Marciniak-Nuqui, Jackie van Dael, Sonja Marjanovic, Sharon Brennan, Sara Shaw   +6 more
doaj   +1 more source

Contextualising Critical Design: Towards a Taxonomy of Critical Practice in Product Design [PDF]

, 2012
This study focuses on critical design practice. The research challenges the colloquial understanding of ‘critical design.’ It problematises, defines and reassesses the concept of ‘critical design’ situating it among other forms of critical design ...
Malpass, Matt, Malpass, M
core  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Treatments for renal cell carcinoma: NICE Pilot Treatment Pathways Appraisal

Health Technology Assessment
Background The National Institute for Health and Care Excellence is piloting a new approach to evaluating health technologies, which takes into consideration the full treatment pathway for a condition.
Dawn Lee, Madhusubramanian Muthukumar, Alan Lovell, Caroline Farmer, Darren Burns, Justin Matthews, Helen Coelho, Brian O’Toole, Laura A Trigg, Tristan M Snowsill, Maxwell S Barnish, Thalia Nikoglou, Amanda Brand, Zain Ahmad, Ahmed Abdelsabour, Louise Crathorne, Sophie Robinson, Edward CF Wilson, GJ Melendez-Torres   +18 more
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

GCN5L: a critical target in energy metabolism pathways

Frontiers in Cell and Developmental Biology
GCN5L (GCN5-like protein), as a core component of a novel epigenetic-regulatory complex, exerts precise control over mitochondrial metabolic enzyme activity through acetylation modifications.
Yushun Kou, Ruiling Ma, Yiyuan Wang, Xiaojie Chen, Bin Li, Tao Wu, Yuanhui Gu, Lin Yi   +7 more
doaj   +1 more source

Analysis of literary productions on the use of therapeutic play in clinical child [PDF]

Revista Gestão & Saúde, 2012
This study aimed to survey and describe the scientific production on the use of therapeutic play as a resource facilitator in assisting the child during the performance ofclinical procedures by the healthteam.the strategy is through the integrative ...
Dione Viero Viana, Gilmar Barbosa de Alencar, Rogério Ferrari   +2 more
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source