Results 81 to 90 of about 6,548,421 (205)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Michael Chekhov in the 21st Century: New Pathways Project

Fleming, C. and Cornford, T. 2013-2016. (Principal Investigators) New Pathways was a ground breaking, major, long-term and multi-organisation research project that ran for three years.
Fleming, Cass, Cornford, Tom
core   +6 more sources

White matter pathways critical for language are also critical for resolving proactive interference in working memory

Frontiers in Psychology, 2014
Background White matter pathways connecting brain regions involved in language processing in the left prefrontal (PFC) and temporal cortices have been found to play a critical role in language comprehension (Turken and Dronkers, 2011). Among the frontal
Stephanie Kathleen Ries, Krista Schendel, Nina F Dronkers   +2 more
doaj   +1 more source

National Adult Critical Care Capacity Census and Activity Census 2016

, 2017
he annual national adult Critical Care Bed Capacity Census measures capacity as at 30th September 2016. The Census reports a capacity of 237 adult critical care (Level3 ICU and Level2 HDU) beds.
HSE Acute Hospitals Division Critical Care Programme
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Barriers to Electrification: Analyzing Critical Delays and Pathways Forward

World Electric Vehicle Journal
This paper extensively explores the intricate nuances surrounding the delayed transition to new business models for electric vehicles. While there is commendable clarity regarding stakeholders, model possibilities, emission-reduction strategies, state ...
Beatriz Amante García, Lluc Canals Casals   +1 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Prehospital time efficiency in the Portuguese Stroke Fast-Track pathway: a nationwide observational study

Journal of Stroke and Cerebrovascular Diseases
Background: Timely prehospital management is critical to improve acute stroke outcomes by minimising time to reperfusion. Despite Stroke Fast-Track pathways, reductions in system response times remain limited. This study aimed to describe system response
Pedro Pires Lavinha, Diana Aguiar de Sousa, Baltazar Nunes, Paulo Boto   +3 more
doaj   +1 more source