Results 81 to 90 of about 2,731,168 (297)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Barriers to and facilitators of the implementation of multi-disciplinary care pathways in primary care: a systematic review

BMC Family Practice, 2020
Background Care pathways (CPWs) are complex interventions that have the potential to reduce treatment errors and optimize patient outcomes by translating evidence into local practice.
Eva Seckler, Verena Regauer, Thomas Rotter, Petra Bauer, Martin Müller   +4 more
doaj   +1 more source

Disease-modifying therapies alter gut microbial composition in MS. [PDF]

, 2019
Objective:To determine the effects of the disease-modifying therapies, glatiramer acetate (GA) and dimethyl fumarate (DMF), on the gut microbiota in patients with MS.
Baranzini, Sergio E, Bencosme, Yadira, Brandstadter, Rachel, Casaccia, Patrizia, Cekanaviciute, Egle, Clemente, Jose C, Crabtree-Hartman, Elizabeth, Cree, Bruce AC, Debelius, Justine, Katz Sand, Ilana, Knight, Rob, Ntranos, Achilles, Singh, Sneha, Zhu, Yunjiao   +13 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Implementation and use of technology-enabled remote monitoring for chronic obstructive pulmonary disease: a rapid qualitative evaluation

Health and Social Care Delivery Research
Background Chronic obstructive pulmonary disease affects around 2% United Kingdom population. Timely identification of patients at risk of deterioration is crucial.
Nikki Newhouse, Agne Ulyte, Zuzanna Marciniak-Nuqui, Jackie van Dael, Sonja Marjanovic, Sharon Brennan, Sara Shaw   +6 more
doaj   +1 more source

More through the door: increasing entry to university geoscience education as a means to address the critical minerals skills shortage

Earth Science, Systems and Society
Critical minerals (CMs) supply is vulnerable to a skills shortage. We focus on (1) the UK situation, where suitable training is provided but numbers taking the university courses have dwindled, and (2) routes through geoscience education into CM careers,
K.R. Moore, K.M. Ryan, F. Wall, R.K. Shail, P.J. Foster   +4 more
doaj   +1 more source

Effects of strand and directional asymmetry on base-base coupling and charge transfer in double-helical DNA [PDF]

, 2002
Mechanistic models of charge transfer (CT) in macromolecules often focus on CT energetics and distance as the chief parameters governing CT rates and efficiencies.
Barton, Jacqueline K., O'Neill, Melanie A.   +1 more
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