Results 71 to 80 of about 7,053,549 (295)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The impact and cost-effectiveness of scaling up HCV treatment for achieving elimination among people who inject drugs in England: a synopsis including evidence synthesis and economic modelling

Health Technology Assessment
Background People who inject drugs are disproportionately affected by hepatitis C virus. The emergence of direct-acting antiviral treatments for hepatitis C virus motivated England to achieve the World Health Organization’s elimination target of ...
Zoe Ward, Ruth Simmons, Hannah Fraser, Adam Trickey, Joanna Kesten, Andrew Gibson, Leila Reid, Sean Cox, Fiona Gordon, Stuart McPherson, Stephen Ryder, Francisco Javier Vilar, Alec Miners, Jack Williams, Beatrice Emmanouil, Monica Desai, Laura Coughlan, Ross Harris, Graham R Foster, Matthew Hickman, Sema Mandal, Peter Vickerman   +21 more
doaj   +1 more source

More through the door: increasing entry to university geoscience education as a means to address the critical minerals skills shortage

Earth Science, Systems and Society
Critical minerals (CMs) supply is vulnerable to a skills shortage. We focus on (1) the UK situation, where suitable training is provided but numbers taking the university courses have dwindled, and (2) routes through geoscience education into CM careers,
K.R. Moore, K.M. Ryan, F. Wall, R.K. Shail, P.J. Foster   +4 more
doaj   +1 more source

CESCA Newsletter

, 2013
On 15 March 2013, the Center for Embedded Systems for Critical Applications is organizing a public event to present its ongoing research projects.. The theme of the symposium is Embedded Security.
Virginia Tech. Center for Embedded Systems for Critical Applications
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Treatments for renal cell carcinoma: NICE Pilot Treatment Pathways Appraisal

Health Technology Assessment
Background The National Institute for Health and Care Excellence is piloting a new approach to evaluating health technologies, which takes into consideration the full treatment pathway for a condition.
Dawn Lee, Madhusubramanian Muthukumar, Alan Lovell, Caroline Farmer, Darren Burns, Justin Matthews, Helen Coelho, Brian O’Toole, Laura A Trigg, Tristan M Snowsill, Maxwell S Barnish, Thalia Nikoglou, Amanda Brand, Zain Ahmad, Ahmed Abdelsabour, Louise Crathorne, Sophie Robinson, Edward CF Wilson, GJ Melendez-Torres   +18 more
doaj   +1 more source

Past and future adaptation pathways [PDF]

, 2015
Adaptation pathways are increasingly being used as a foresight tool to help guide the implementation of climate change adaptation and deliberate transformation.
Davies, T.E., Moug, Peter, Câmpeanu, C., Moug, P., Wise, R.M., Wise, Russell M., Lyon, Christopher, Fazey, I., Lyon, C., Fazey, Ioan R. A., Davies, Tammy E., Campeanu, Claudia   +11 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Implementation and use of technology-enabled remote monitoring for chronic obstructive pulmonary disease: a rapid qualitative evaluation

Health and Social Care Delivery Research
Background Chronic obstructive pulmonary disease affects around 2% United Kingdom population. Timely identification of patients at risk of deterioration is crucial.
Nikki Newhouse, Agne Ulyte, Zuzanna Marciniak-Nuqui, Jackie van Dael, Sonja Marjanovic, Sharon Brennan, Sara Shaw   +6 more
doaj   +1 more source

Analysis of literary productions on the use of therapeutic play in clinical child [PDF]

Revista Gestão & Saúde, 2012
This study aimed to survey and describe the scientific production on the use of therapeutic play as a resource facilitator in assisting the child during the performance ofclinical procedures by the healthteam.the strategy is through the integrative ...
Dione Viero Viana, Gilmar Barbosa de Alencar, Rogério Ferrari   +2 more
doaj