Results 51 to 60 of about 2,731,168 (297)

Sestrins are evolutionarily conserved mediators of exercise benefits. [PDF]

, 2020
Exercise is among the most effective interventions for age-associated mobility decline and metabolic dysregulation. Although long-term endurance exercise promotes insulin sensitivity and expands respiratory capacity, genetic components and pathways ...
Brooks, Susan V, Cho, Chun-Seok, Cobb, Tyler, Davis, Carol, Gu, Bondong, Karin, Michael, Kim, Boyoung, Kim, Myungjin, Kowalsky, Allison H, Lee, Jun Hee, Namkoong, Sim, Ro, Seung-Hyun, Semple, Ian, Sujkowski, Alyson, Wessells, Robert J   +14 more
core   +2 more sources

Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer. [PDF]

, 2015
BackgroundUnderstanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics.
Akagi, Naomi, Bauer, Jessica, Carroll, Timothy, Eckmann, Lars, Grippo, Paul J, Jung, Barbara, Ozden, Ozkan, Principe, Daniel R, Spehlmann, Martina E, Staudacher, Jonas J   +9 more
core   +2 more sources

Defining Roles in Pediatric Palliative Care: Perspectives From Oncology and Palliative Care Teams

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Early integration of pediatric palliative care (PPC) is associated with improved symptom management, quality of life, and healthcare utilization for children with cancer. Despite this, variation persists in how PPC is understood, operationalized, and integrated within pediatric oncology programs. In particular, ambiguity surrounding
Leeat Granek, Lori Wiener, Stephanie Veldhuijzen van Zanten, Donna Johnston, Fyeza Hasan, Adam Rapoport, Nathasha Datoo, Kimberley Widger, Sumit Gupta, Karen Fergus, Anthony K. C. Chan, Alisha Kassam, Emily McCullogh, Dave Lysecki   +13 more
wiley   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Avaliação não invasiva de pacientes submetidos à intervenção percutânea no infarto do miocárdio Noninvasive assessment of patients undergoing percutaneous intervention in myocardial infarction

Arquivos Brasileiros de Cardiologia, 2010
FUNDAMENTO: A reestenose pós-intervenção coronariana percutânea primária permanece um problema de relevância clínica, mesmo com o implante de stents.
Rica Dodo Delmar Buchler, Expedito E. Ribeiro, Antonio de Padua Mansur, Paola Smanio, Romeu Sergio Meneghelo, William Azem Chalela, Carlos Alberto Buchpiguel, Jorge Roberto Buchler, Eric R. Bates, Eulogio E. Martinez   +9 more
doaj  

Assessing the reproducibility, stability, and biological interpretability of multimodal computed tomography image features for prognosis in advanced non‐small cell lung cancer

iRADIOLOGY
Background Despite the existence of proposed prognostic features on computed tomography (CT) for patients with advanced‐stage non‐small cell lung cancer (NSCLC), including radiologists' handcrafted (RaH) features, radiomics features, and deep learning ...
Jiajun Wang, Gang Dai, Xiufang Ren, Ruichuan Shi, Ruibang Luo, Jianhua Liu, Kexue Deng, Jiangdian Song   +7 more
doaj   +1 more source

Transcriptomic analysis of field-droughted sorghum from seedling to maturity reveals biotic and metabolic responses. [PDF]

, 2019
Drought is the most important environmental stress limiting crop yields. The C4 cereal sorghum [Sorghum bicolor (L.) Moench] is a critical food, forage, and emerging bioenergy crop that is notably drought-tolerant.
Baker, Christopher R, Blow, Matthew J, Cole, Benjamin, Coleman-Derr, Devin, Dahlberg, Jeffery, DeGraaf, Stephanie, Gao, Cheng, Harrison, Maria J, Hollingsworth, Joy, Hutmacher, Robert, Jansson, Christer, Jeffers, Tim, Lemaux, Peggy G, Madera, Mary, Niyogi, Krishna K, O'Malley, Ronan C, Owiti, Judith A, Patel, Dhruv, Pierroz, Grady, Purdom, Elizabeth, Sievert, Julie, Singan, Vasanth R, Taylor, John W, Varoquaux, Nelle, Visel, Axel, Vogel, John P, Xu, Ling, Yoshinaga, Yuko   +27 more
core   +3 more sources

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Molecular responses of mouse macrophages to copper and copper oxide nanoparticles inferred from proteomic analyses [PDF]

, 2013
The molecular responses of macrophages to copper-based nanoparticles have been investigated via a combination of proteomic and biochemical approaches, using the RAW264.7 cell line as a model.
Aude-Garcia, Catherine, Carrière, Marie, Chevallet, Mireille, Collin-Faure, Véronique, Diemer, Hélène, Habert, Aurélie, Hanau, Daniel, Herlin-Boime, Nathalie, Proamer, Fabienne, Rabilloud, Thierry, Strub, Jean-Marc, Triboulet, Sarah, Van Dorsselaer, Alain   +12 more
core   +5 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source