Results 51 to 60 of about 6,548,421 (205)

Reconceptualising adaptation to climate change as part of pathways of change and response [PDF]

, 2014
The need to adapt to climate change is now widely recognised as evidence of its impacts on social and natural systems grows and greenhouse gas emissions continue unabated.
Park, Sarah, Park, S.E., Wise, RM, Fazey, I, Campbell, Bruce M., Park, S. E., Campbell, Bruce Morgan, Park, SE, Archer Van Garderen, ERM, Smith, M. Stafford, Eakin, H.C., Stafford Smith, M.D., Archer Van Garderen, E. R. M., Campbell, B., Wise, R.M., Van Garderen, E.R.M. Archer, Eakin, H. C., Fazey, I., Stafford Smith, M., Wise, R. M.   +19 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Struggling for a feasible tool – the process of implementing a clinical pathway in intensive care: a grounded theory study

BMC Health Services Research, 2018
Background Clinical pathways can enhance care quality, promote patient safety and optimize resource utilization. However, they are infrequently utilized in intensive care. This study aimed to explain the implementation process of a clinical pathway based
Petronella Bjurling-Sjöberg, Barbro Wadensten, Ulrika Pöder, Inger Jansson, Lena Nordgren   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Critical signaling pathways governing hepatocellular carcinoma behavior; small molecule-based approaches

Cancer Cell International, 2021
Hepatocellular carcinoma (HCC) is the second leading cause of death due to cancer. Although there are different treatment options, these strategies are not efficient in terms of restricting the tumor cell’s proliferation and metastasis.
Zahra Farzaneh, Massoud Vosough, Tarun Agarwal, Maryam Farzaneh   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Peacebuilding, Politicisation and Youth Work: Pathways to youth critical action for sustainable peace in Northern Ireland [PDF]

While Northern Ireland is praised as a successful peace process with valuable lessons, peacebuilding is incomplete. The responsibility increasingly falls on young people to address the unfinished business of the past, despite questions of capacity and ...
Hamber, Brandon; id_orcid, McArdle, Eliz; id_orcid, Hamilton, Andy; id_orcid   +2 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Identification of signalling pathways regulating TBX2 gene expression and its target genes [PDF]

, 2008
Includes abstract.Includes bibliographical references (leaves 83-97).Members of the T-box family of transcription factors provide an important link between development and cancer.
Teng, Huajian
core   +1 more source