Results 31 to 40 of about 6,548,421 (205)

Impact of Initial Treatment Setting on Survival in Relapsed Pediatric and AYA Bone Sarcomas: A Secondary Analysis of a Prospective Clinical Trial

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Outcomes in relapsed or refractory pediatric and AYA bone sarcomas remain poor, and the impact of early referral to specialized sarcoma centers on survival is unclear. Early centralization of care may improve local and systemic treatment quality, but evidence in this population is limited.
Justyna Antoniuk‐Majchrzak, Katarzyna Bilska, Tomasz Koziński, Jadwiga Węcławek‐Tompol, Dorota Sega‐Pondel, Radosław Chaber, Wanda Badowska, Katarzyna Rosłan, Hanna Koseła‐Paterczyk, Anna Raciborska   +9 more
wiley   +1 more source

XA4C-identified critical genes in pathways associated with copy number variations, differential methylation, and genetic mutations from COSMIC database.

, 2023
XA4C-identified critical genes in pathways associated with copy number variations, differential methylation, and genetic mutations from COSMIC database.
Wenyuan Liao (6009893), Theodore Lun (17081588), Yang Yu (4292), Qing Li (84975), Pathum Kossinna (17081585), Qingrun Zhang (82414)   +5 more
core   +1 more source

Representation of Sickle Cell Disease Patients in Pediatric and Adult Care: What We Discovered Using Informatics for Integrating Biology and the Bedside (i2b2) Data

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Transitioning from pediatric to adult care is a high‐risk period for individuals with sickle cell disease (SCD). An initial observation at one academic medical center suggested a sex‐based disparity in clinic populations, prompting a national investigation.
Laurie J. Duckworth, Kholod Alhassan, Ada De La Osa, John Stephen, Yue Yao, Diana J. Wilkie   +5 more
wiley   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Recent Advances on Alternative Aviation Fuels/Pathways: A Critical Review

Energies, 2023
The Paris Agreement’s objectives related to climate change put aviation under great pressure and environmental inspection. In particular, the aviation industry is committed to achieving a 50% reduction in CO2 emissions by 2050 compared to 2005 levels.
Nikolaos Detsios, Stella Theodoraki, Leda Maragoudaki, Konstantinos Atsonios, Panagiotis Grammelis, Nikolaos G. Orfanoudakis   +5 more
doaj   +1 more source

Critical nodes discovery in pathophysiological signaling pathways

, 2019
Network-based ranking methods (e.g. centrality analysis) have found extensive use in systems medicine for the prediction of essential proteins, for the prioritization of drug targets candidates in the treatment of several pathologies and in biomarker ...
Marco Cianfriglia, Alessandro Celestini, Alessandro Palma, Enrico Mastrostefano, Paolo Tieri   +4 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The development, implementation and evaluation of clinical pathways for chronic obstructive pulmonary disease (COPD) in Saskatchewan: protocol for an interrupted times series evaluation

BMC Health Services Research, 2017
Background Chronic obstructive pulmonary disease (COPD) has substantial economic and human costs; it is expected to be the third leading cause of death worldwide by 2030. To minimize these costs high quality guidelines have been developed.
Thomas Rotter, Christopher Plishka, Mohammed Rashaad Hansia, Donna Goodridge, Erika Penz, Leigh Kinsman, Adegboyega Lawal, Sheryl O’Quinn, Nancy Buchan, Patricia Comfort, Prakesh Patel, Sheila Anderson, Tanya Winkel, Rae Lynn Lang, Darcy D. Marciniuk   +14 more
doaj   +1 more source

Occupational Therapy Benchmarks Within Orthopedic (Hip) Critical Pathways

, 2000
Objective. This study examined patient performance benchmarks for occupational therapy within orthopedic (hip) critical pathways. Method. Eight orthopedic (hip) critical pathways gathered from occupational therapy practitioners working in ...
Lee Morris, Sharon D. Novalis, Michele Fricke Messenger   +2 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source