Modelling and analysis of biochemical signalling pathway cross-talk [PDF]
, 2010 Signalling pathways are abstractions that help life scientists structure the coordination of cellular activity. Cross-talk between pathways accounts for many of the complex behaviours exhibited by signalling pathways and is often critical in producing ...
Emanuela Merelli +3 more
core +5 more sources
Pathways into multiple exclusion homelessness in seven UK cities [PDF]
, 2012 This paper interrogates pathways into multiple exclusion homelessness (MEH) in the UK and, informed by a critical realist theoretical framework, explores the potential causal processes underlying these pathways.
Bramley, Glen +2 more
core +1 more source
Making the most of community energies:Three perspectives on grassroots innovation [PDF]
, 2016 Grassroots innovations for sustainability are attracting increasing policy attention. Drawing upon a wide range of empirical research into community energy in the UK, and taking recent support from national government as a case study, we apply three ...
Abramsky K +13 more
core +1 more source
“What if There's Something Wrong with Her?”‐How Biomedical Technologies Contribute to Epistemic Injustice in Healthcare [PDF]
, 2020 While there is a steadily growing literature on epistemic injustice in healthcare, there are few discussions of the role that biomedical technologies play in harming patients in their capacity as knowers.
Alexander Michelle +33 more
core +1 more source
Why fish? Using entry-strategies to inform governance of the small-scale sector: A case-study in the Bijagós Archipelago (West Africa) [PDF]
, 2014 Should rural commercial small-scale fishing opportunities be closed to minimise effort and safeguard marine resources or open to offer livelihood support?
Cross, H
core +1 more source
Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest [PDF]
, 2015 TGFbeta is critical to control hepatocyte proliferation by inducing G1-growth arrest through multiple pathways leading to inhibition of E2F transcription activity.
Bellamy, Christopher O +4 more
core +1 more source
Optimization of carbon and energy utilization through differential translational efficiency. [PDF]
, 2018 Control of translation is vital to all species. Here we employ a multi-omics approach to decipher condition-dependent translational regulation in the model acetogen Clostridium ljungdahlii.
Al-Bassam, Mahmoud M +7 more
core +2 more sources
Src as the link between inflammation and cancer. [PDF]
, 2013 Although a causal link between chronic inflammation and cancer has been established, the exact molecular mechanism linking inflammation to cancer remains largely unknown.
Andrzej ePtasznik +4 more
core +2 more sources
Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition [PDF]
, 2017 Accumulation and deposition of amyloid-β (Aβ) in the brain represent an early and perhaps necessary step in the pathogenesis of Alzheimer's disease (AD).
Bu, Guojun +8 more
core +2 more sources
Nursing Management (Springhouse), 1998 Hospital managers initiate a nurse orientation program modeled after critical pathways. The structure allows them to assess nurses' competency while providing experience.
R J, Francis, C, Batsie
openaire +3 more sources