The Critical Pathways of Deceased Organ Donation in Saudi Arabia
Saudi Journal of Kidney Diseases and Transplantation, 2022 Besher Al Attar
doaj +1 more source
Cardiovascular critical event pathways for the progression of heart failure; a report from the ATLAS study [PDF]
, 2001 John G.F. Cleland +7 more
openalex +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Identification of Critical Pathways and Hub Genes in LanCL1-Overexpressed Prostate Cancer Cells. [PDF]
Onco Targets Ther, 2020 Tang R +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Palmitoylation of CCR5 Is Critical for Receptor Trafficking and Efficient Activation of Intracellular Signaling Pathways [PDF]
, 2001 Cédric Blanpain +11 more
openalex +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Argumentation as a pathway to critical thinking
, 2019 Based on insights from the field of educational psychology, we designed and implemented an eightweek, small-scale intervention for first year university students in educational sciences. Critical thinking and argumentation skills were fostered through small-group classroom discussions.
Ferguson, Leila Eve +1 more
openaire +2 more sources
6-O-Sulfotransferase-1 Represents a Critical Enzyme in the Anticoagulant Heparan Sulfate Biosynthetic Pathway [PDF]
, 2001 Lijuan Zhang +8 more
openalex +1 more source
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source