Results 181 to 190 of about 2,672,882 (329)

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Prefronto-thalamic hypoconnectivity in schizophrenia: Monkey to human translation of critical pathways for symptom-related functions. [PDF]

PCN Rep
Yahata N, Hirabayashi T, Minamimoto T.
europepmc   +1 more source

Author response: G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs

Yihong Li, Yi-Sen Yang, Yanbo Xue, Lei Hao, Saisai Zhang, Junbin Qian, Yushi Yao, Ruhong Zhou, Liquan Huang   +8 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Supplemental Table S1 from PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways

, 2023
Brajesh P. Kaistha, Holger Lorenz, Harald Schmidt, Bence Sipos, Michael Pawlak, Berthold Gierke, Ramona Kreider, Brigitte Lankat–Buttgereit, Melanie Sauer, Lisa Fiedler, Anja Krattenmacher, Bettina Geisel, Johann M. Kraus, Kristopher K. Frese, Sabine Kelkenberg, Nathalia A. Giese, Hans A. Kestler, Thomas M. Gress, Malte Buchholz   +18 more
openalex   +2 more sources

Life After COVID-19: Rethinking the Healthcare System and Valuing the Role of Citizens' Engagement in Health Prevention

Frontiers in Psychology, 2020
Floriana D'Ambrosio, Antonio Giulio de Belvis, Antonio Giulio de Belvis, Alisha Morsella, Alisha Morsella, Greta Castellini, Guendalina Graffigna, Patrizia Laurenti, Patrizia Laurenti   +8 more
doaj   +1 more source

Comparison the impact of IFN-β alone or in combination with vitamin D on critical pathways involved in AML progression. [PDF]

PLoS One
Nasri F, Jalaeikhoo H, Dadmanesh M, Behranvand N, Falak R, Rouzbahan NH, Babaei Y, Ghorban K.   +7 more
europepmc   +1 more source

The Phosphoinositol-3-Kinase–Protein Kinase B/Akt Pathway Is Critical for Pseudomonas aeruginosa Strain PAK Internalization [PDF]

, 2005
Arlinet Kierbel, Ama Gassama‐Diagne, Keith E. Mostov, Joanne N. Engel   +3 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Critical Pathways for Transforming the Energy Future: A Review of Innovations and Challenges in Spent Lithium Battery Recycling Technologies. [PDF]

Materials (Basel)
Lu Z, Ning L, Zhu X, Yu H.
europepmc   +1 more source