Results 191 to 200 of about 2,672,882 (329)

Longitudinal transcriptional changes reveal genes from the natural killer cell-mediated cytotoxicity pathway as critical players underlying COVID-19 progression [PDF]

Matías A. Medina, Francisco Fuentes‐Villalobos, Claudio Quevedo, Felipe Aguilera, Raúl Riquelme, María Luisa Rioseco, Sebastian Barria, Yazmín Pinos, Mario Calvo, Ian Burbulis, Raymond Alvarez, José Luis Velasco Garrido, María Inés Barría, Jose Luis Garrido, Maria Ines Barria   +14 more
openalex   +1 more source

The PIM1 Kinase Is a Critical Component of a Survival Pathway Activated by Docetaxel and Promotes Survival of Docetaxel-treated Prostate Cancer Cells [PDF]

, 2008
Marina Zemskova, Eva Sahakian, Svetlana Bashkirova, Michelle M. Lilly   +3 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Systems biology approach delineates critical pathways associated with papillary thyroid cancer: a multi-omics data analysis. [PDF]

Thyroid Res
Payva F, K S S, James R, E AP, Sivaramakrishnan V.   +4 more
europepmc   +1 more source

Critical role of the CD40–CD40-ligand pathway in regulating mucosal inflammation-driven angiogenesis in inflammatory bowel disease [PDF]

, 2007
Silvio Danese, Franco Scaldaferri, Stefania Vetrano, Tommaso Stefanelli, C. Graziani, Alessandro Repici, R. Ricci, Giuseppe Straface, Alessandro Sgambato, Alberto Malesci, Claudio Fiocchi, Sergio Rutella   +11 more
openalex   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Comparative Transcriptome Analysis of Henosepilachna vigintioctomaculata Reveals Critical Pathways during Development. [PDF]

Int J Mol Sci
Zhang YX, Wu YK, Liu HH, Li WZ, Jin L, Li GQ.   +5 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Unveiling the Critical Pathways of Hydroxyl Radical Formation in Breakpoint Chlorination: The Role of Trichloramine and Dichloramine Interactions. [PDF]

Environ Sci Technol
Chuang YH, Chou CS, Chu YL.
europepmc   +1 more source

Sputum Exosomal microRNAs Profiling Reveals Critical Pathways Modulated By Pseudomonas aeruginosa Colonization In Bronchiectasis. [PDF]

Int J Chron Obstruct Pulmon Dis, 2019
Huang Y, Chen CL, Yuan JJ, Li HM, Han XR, Chen RC, Guan WJ, Zhong NS.   +7 more
europepmc   +1 more source