Landscape of BRAF transcript variants in human cancer
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda+5 more
wiley +1 more source
Interferon regulatory factor 4 modulates epigenetic silencing and cancer-critical pathways in melanoma cells. [PDF]
Sobhiafshar U+10 more
europepmc +1 more source
Comparative Proteomic Analysis Unveils Critical Pathways Underlying the Role of Nitrogen Fertilizer Treatment in American Elderberry. [PDF]
Yang B, Thomas AL, Greenlief CM.
europepmc +1 more source
Mapping critical biological motifs and biosynthetic pathways of heparan sulfate [PDF]
Roger Lawrence
openalex +1 more source
CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki+2 more
wiley +1 more source
Potential and critical pathways of CO2 emissions reduction: A city-based study
China has put forward the ''Dual Carbon'' target, carbon peak by 2030 and carbon neutrality by 2060. It is necessary to study the current situation of carbon emissions, carbon reduction potential, and decarbonization paths of industrial cities in China ...
Yangdi Zhou+7 more
doaj
MicroRNA biogenesis pathways in cancer
Shuibin Lin, R. Gregory
semanticscholar +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo+18 more
wiley +1 more source
Developmental transcriptomic analyses for mechanistic insights into critical pathways involved in embryogenesis of pelagic mahi-mahi (Coryphaena hippurus). [PDF]
Xu EG+6 more
europepmc +1 more source