LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Critical behavior of rumor propagation on random networks of cliques
Papers in PhysicsWe disclose a critical phenomenon induced by structural properties of the contact pattern in a stylized model of rumor propagation over a population of agents.
Lucas A. Sobehart, Damián H. Zanette
doaj +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Liquid-gas state regularities as a manifestation of global isomorphism with the Ising model
Condensed Matter PhysicsLiquid-gas equilibrium is considered using the global isomorphism with the Ising-like (lattice gas) model. Such an approach assumes the existence of the order parameter in terms of which the symmetry of binodal is restored not only in the vicinity of ...
L. A. Bulavin +3 more
doaj +1 more source
Strain Fields and Critical Phenomena in Manganites I: Spin-Lattice Hamiltonians [PDF]
, 2022 Rohit Kumar Singh, Sanjay Puri
openalex +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Analysis of the 3d massive renormalization group perturbative expansions: a delicate case
Condensed Matter Physics, 2010 The effectiveness of the perturbative renormalization group approach at fixed space dimension d in the theory of critical phenomena is analyzed. Three models are considered: the O(N) model, the cubic model and the antiferromagnetic model defined on the ...
B. Delamotte +3 more
doaj +1 more source
Local vs. Long-Range Infection in Unidimensional Epidemics
Frontiers in Physics, 2019 We study the effects of local and distance interactions in the unidimensional contact process (CP). In the model, each site of a lattice is occupied by an individual, which can be healthy or infected.
Priscila R. Silveira +2 more
doaj +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source