Results 181 to 190 of about 15,117,675 (273)

Navigating pelvic anatomy for exenteration: a clinical guide for radiologists. [PDF]

Br J Radiol
Nougaret S, Wood V, Rouanet P, Aalbers AGJ, Glyn T, Tolan D, Lambregts DMJ.   +6 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Intermuscular dissection by transanal endoscopic operation for a rectal lesion. [PDF]

Tech Coloproctol
Vaccaro A, Gonzalez Salazar E, Caram L, Campana JP, Mentz R, Rossi G.   +5 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Uniaxial Stress Enhanced Anisotropic Magnetoresistance and Superconductivity in the Kagome Superconductor LaRu₃Si₂. [PDF]

Adv Mater
Kral P, Sazgari V, Ge Y, Gerguri O, Spitaler M, Graham JN, Nakamura H, Bartkowiak M, Nakatsuji S, Luetkens H, Simutis G, Xu G, Guguchia Z.   +12 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Neuromorphic vision with quasi-BICs. [PDF]

Light Sci Appl
Li J, Qin H, Song Q.
europepmc   +1 more source

F405 Fatigue crack initiation life prediction of rails using theory of critical distance and critical plane approach

The Proceedings of The Computational Mechanics Conference, 2011
AKAMA, Makoto, MATSUDA, Hiroyuki, DOI, Hisayo, TSUJIE, Masahiro   +3 more
openaire   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source